6TCA
Phosphorylated p38 and MAPKAPK2 complex with inhibitor
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C, E, G | MAP kinase-activated protein kinase 2 | polymer | 371 | 42889.5 | 4 | UniProt (P49137) Pfam (PF00069) In PDB | Homo sapiens (Human) | MK2 |
2 | B, D, F, H | Mitogen-activated protein kinase 14 | polymer | 364 | 41805.4 | 4 | UniProt (Q16539) Pfam (PF00069) In PDB | Homo sapiens (Human) | MAPK 14,Cytokine suppressive anti-inflammatory drug-binding protein,CSBP,MAP kinase MXI2,MAX-interacting protein 2,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha,Stress-activated protein kinase 2a,SAPK2a |
3 | B, D, F, H | N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide | non-polymer | 426.5 | 4 | Chemie (39G) |
Sequence modifications
A, C, E, G: 41 - 400 (UniProt: P49137)
B, D, F, H: 1 - 360 (UniProt: Q16539)
PDB | External Database | Details |
---|---|---|
Gly 39 | - | expression tag |
Ser 40 | - | expression tag |
Gly 401 | - | expression tag |
Ser 402 | - | expression tag |
Arg 403 | - | expression tag |
His 404 | - | expression tag |
His 405 | - | expression tag |
His 406 | - | expression tag |
His 407 | - | expression tag |
His 408 | - | expression tag |
His 409 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Ala -1 | - | expression tag |
Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 338779.8 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1706.1 | |
All* | Total formula weight | 340485.9 |