6TCA

Phosphorylated p38 and MAPKAPK2 complex with inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C, E, G (A, C, E, G)	MAP kinase-activated protein kinase 2	polymer	371	42889.5	4	UniProt (P49137) Pfam (PF00069)	Homo sapiens (Human)	MK2
2	B, D, F, H (B, D, F, H)	Mitogen-activated protein kinase 14	polymer	364	41805.4	4	UniProt (Q16539) Pfam (PF00069)	Homo sapiens (Human)	MAPK 14,Cytokine suppressive anti-inflammatory drug-binding protein,CSBP,MAP kinase MXI2,MAX-interacting protein 2,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha,Stress-activated protein kinase 2a,SAPK2a
3	I, J, K, L (B, D, F, H)	N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide	non-polymer		426.5	4	Chemie (39G)

Sequence modifications

A, C, E, G: 41 - 400 (UniProt: P49137)

PDB	External Database	Details
Gly 39	-	expression tag
Ser 40	-	expression tag
Gly 401	-	expression tag
Ser 402	-	expression tag
Arg 403	-	expression tag
His 404	-	expression tag
His 405	-	expression tag
His 406	-	expression tag
His 407	-	expression tag
His 408	-	expression tag
His 409	-	expression tag

B, D, F, H: 1 - 360 (UniProt: Q16539)

PDB	External Database	Details
Gly -3	-	expression tag
Ser -2	-	expression tag
Ala -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	338779.8
Non-Polymers*	Number of molecules	4
	Total formula weight	1706.1
All*	Total formula weight	340485.9

*Water molecules are not included.