6TCA

Phosphorylated p38 and MAPKAPK2 complex with inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000165	biological_process	MAPK cascade
A	0000166	molecular_function	nucleotide binding
A	0002224	biological_process	toll-like receptor signaling pathway
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004683	molecular_function	calcium/calmodulin-dependent protein kinase activity
A	0005515	molecular_function	protein binding
A	0005516	molecular_function	calmodulin binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0006468	biological_process	protein phosphorylation
A	0006691	biological_process	leukotriene metabolic process
A	0006954	biological_process	inflammatory response
A	0006974	biological_process	DNA damage response
A	0009931	molecular_function	calcium-dependent protein serine/threonine kinase activity
A	0010803	biological_process	regulation of tumor necrosis factor-mediated signaling pathway
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0032496	biological_process	response to lipopolysaccharide
A	0032675	biological_process	regulation of interleukin-6 production
A	0032680	biological_process	regulation of tumor necrosis factor production
A	0032760	biological_process	positive regulation of tumor necrosis factor production
A	0034097	biological_process	response to cytokine
A	0035556	biological_process	intracellular signal transduction
A	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
A	0036064	cellular_component	ciliary basal body
A	0038066	biological_process	p38MAPK cascade
A	0043488	biological_process	regulation of mRNA stability
A	0044351	biological_process	macropinocytosis
A	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
A	0048255	biological_process	mRNA stabilization
A	0048839	biological_process	inner ear development
A	0051019	molecular_function	mitogen-activated protein kinase binding
A	0060907	biological_process	positive regulation of macrophage cytokine production
A	0070062	cellular_component	extracellular exosome
A	0070935	biological_process	3'-UTR-mediated mRNA stabilization
A	0106310	molecular_function	protein serine kinase activity
A	1900034	biological_process	regulation of cellular response to heat
B	0000077	biological_process	DNA damage checkpoint signaling
B	0000165	biological_process	MAPK cascade
B	0000166	molecular_function	nucleotide binding
B	0000902	biological_process	cell morphogenesis
B	0000922	cellular_component	spindle pole
B	0001502	biological_process	cartilage condensation
B	0001525	biological_process	angiogenesis
B	0001649	biological_process	osteoblast differentiation
B	0001890	biological_process	placenta development
B	0002021	biological_process	response to dietary excess
B	0002062	biological_process	chondrocyte differentiation
B	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004707	molecular_function	MAP kinase activity
B	0004708	molecular_function	MAP kinase kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006006	biological_process	glucose metabolic process
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006366	biological_process	transcription by RNA polymerase II
B	0006468	biological_process	protein phosphorylation
B	0006915	biological_process	apoptotic process
B	0006935	biological_process	chemotaxis
B	0006974	biological_process	DNA damage response
B	0007165	biological_process	signal transduction
B	0007166	biological_process	cell surface receptor signaling pathway
B	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
B	0007519	biological_process	skeletal muscle tissue development
B	0010628	biological_process	positive regulation of gene expression
B	0010831	biological_process	positive regulation of myotube differentiation
B	0016301	molecular_function	kinase activity
B	0016607	cellular_component	nuclear speck
B	0016740	molecular_function	transferase activity
B	0019395	biological_process	fatty acid oxidation
B	0019899	molecular_function	enzyme binding
B	0019903	molecular_function	protein phosphatase binding
B	0030168	biological_process	platelet activation
B	0030278	biological_process	regulation of ossification
B	0030316	biological_process	osteoclast differentiation
B	0031098	biological_process	stress-activated protein kinase signaling cascade
B	0031281	biological_process	positive regulation of cyclase activity
B	0031663	biological_process	lipopolysaccharide-mediated signaling pathway
B	0032495	biological_process	response to muramyl dipeptide
B	0032496	biological_process	response to lipopolysaccharide
B	0032735	biological_process	positive regulation of interleukin-12 production
B	0032868	biological_process	response to insulin
B	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
B	0034774	cellular_component	secretory granule lumen
B	0035331	biological_process	negative regulation of hippo signaling
B	0035556	biological_process	intracellular signal transduction
B	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
B	0035994	biological_process	response to muscle stretch
B	0038066	biological_process	p38MAPK cascade
B	0042307	biological_process	positive regulation of protein import into nucleus
B	0042770	biological_process	signal transduction in response to DNA damage
B	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
B	0045648	biological_process	positive regulation of erythrocyte differentiation
B	0045663	biological_process	positive regulation of myoblast differentiation
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0046323	biological_process	D-glucose import
B	0046326	biological_process	positive regulation of D-glucose import
B	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
B	0048273	molecular_function	mitogen-activated protein kinase p38 binding
B	0048863	biological_process	stem cell differentiation
B	0051146	biological_process	striated muscle cell differentiation
B	0051149	biological_process	positive regulation of muscle cell differentiation
B	0051403	biological_process	stress-activated MAPK cascade
B	0051525	molecular_function	NFAT protein binding
B	0060045	biological_process	positive regulation of cardiac muscle cell proliferation
B	0060348	biological_process	bone development
B	0070935	biological_process	3'-UTR-mediated mRNA stabilization
B	0071222	biological_process	cellular response to lipopolysaccharide
B	0071223	biological_process	cellular response to lipoteichoic acid
B	0071356	biological_process	cellular response to tumor necrosis factor
B	0071479	biological_process	cellular response to ionizing radiation
B	0071493	biological_process	cellular response to UV-B
B	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
B	0090336	biological_process	positive regulation of brown fat cell differentiation
B	0090398	biological_process	cellular senescence
B	0090400	biological_process	stress-induced premature senescence
B	0098586	biological_process	cellular response to virus
B	0098978	cellular_component	glutamatergic synapse
B	0099179	biological_process	regulation of synaptic membrane adhesion
B	0106310	molecular_function	protein serine kinase activity
B	1900015	biological_process	regulation of cytokine production involved in inflammatory response
B	1901741	biological_process	positive regulation of myoblast fusion
B	1904813	cellular_component	ficolin-1-rich granule lumen
B	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
C	0000165	biological_process	MAPK cascade
C	0000166	molecular_function	nucleotide binding
C	0002224	biological_process	toll-like receptor signaling pathway
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004683	molecular_function	calcium/calmodulin-dependent protein kinase activity
C	0005515	molecular_function	protein binding
C	0005516	molecular_function	calmodulin binding
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005813	cellular_component	centrosome
C	0005829	cellular_component	cytosol
C	0006468	biological_process	protein phosphorylation
C	0006691	biological_process	leukotriene metabolic process
C	0006954	biological_process	inflammatory response
C	0006974	biological_process	DNA damage response
C	0009931	molecular_function	calcium-dependent protein serine/threonine kinase activity
C	0010803	biological_process	regulation of tumor necrosis factor-mediated signaling pathway
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0032496	biological_process	response to lipopolysaccharide
C	0032675	biological_process	regulation of interleukin-6 production
C	0032680	biological_process	regulation of tumor necrosis factor production
C	0032760	biological_process	positive regulation of tumor necrosis factor production
C	0034097	biological_process	response to cytokine
C	0035556	biological_process	intracellular signal transduction
C	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
C	0036064	cellular_component	ciliary basal body
C	0038066	biological_process	p38MAPK cascade
C	0043488	biological_process	regulation of mRNA stability
C	0044351	biological_process	macropinocytosis
C	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
C	0048255	biological_process	mRNA stabilization
C	0048839	biological_process	inner ear development
C	0051019	molecular_function	mitogen-activated protein kinase binding
C	0060907	biological_process	positive regulation of macrophage cytokine production
C	0070062	cellular_component	extracellular exosome
C	0070935	biological_process	3'-UTR-mediated mRNA stabilization
C	0106310	molecular_function	protein serine kinase activity
C	1900034	biological_process	regulation of cellular response to heat
D	0000077	biological_process	DNA damage checkpoint signaling
D	0000165	biological_process	MAPK cascade
D	0000166	molecular_function	nucleotide binding
D	0000902	biological_process	cell morphogenesis
D	0000922	cellular_component	spindle pole
D	0001502	biological_process	cartilage condensation
D	0001525	biological_process	angiogenesis
D	0001649	biological_process	osteoblast differentiation
D	0001890	biological_process	placenta development
D	0002021	biological_process	response to dietary excess
D	0002062	biological_process	chondrocyte differentiation
D	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
D	0004672	molecular_function	protein kinase activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0004707	molecular_function	MAP kinase activity
D	0004708	molecular_function	MAP kinase kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0006006	biological_process	glucose metabolic process
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0006366	biological_process	transcription by RNA polymerase II
D	0006468	biological_process	protein phosphorylation
D	0006915	biological_process	apoptotic process
D	0006935	biological_process	chemotaxis
D	0006974	biological_process	DNA damage response
D	0007165	biological_process	signal transduction
D	0007166	biological_process	cell surface receptor signaling pathway
D	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
D	0007519	biological_process	skeletal muscle tissue development
D	0010628	biological_process	positive regulation of gene expression
D	0010831	biological_process	positive regulation of myotube differentiation
D	0016301	molecular_function	kinase activity
D	0016607	cellular_component	nuclear speck
D	0016740	molecular_function	transferase activity
D	0019395	biological_process	fatty acid oxidation
D	0019899	molecular_function	enzyme binding
D	0019903	molecular_function	protein phosphatase binding
D	0030168	biological_process	platelet activation
D	0030278	biological_process	regulation of ossification
D	0030316	biological_process	osteoclast differentiation
D	0031098	biological_process	stress-activated protein kinase signaling cascade
D	0031281	biological_process	positive regulation of cyclase activity
D	0031663	biological_process	lipopolysaccharide-mediated signaling pathway
D	0032495	biological_process	response to muramyl dipeptide
D	0032496	biological_process	response to lipopolysaccharide
D	0032735	biological_process	positive regulation of interleukin-12 production
D	0032868	biological_process	response to insulin
D	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
D	0034774	cellular_component	secretory granule lumen
D	0035331	biological_process	negative regulation of hippo signaling
D	0035556	biological_process	intracellular signal transduction
D	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
D	0035994	biological_process	response to muscle stretch
D	0038066	biological_process	p38MAPK cascade
D	0042307	biological_process	positive regulation of protein import into nucleus
D	0042770	biological_process	signal transduction in response to DNA damage
D	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
D	0045648	biological_process	positive regulation of erythrocyte differentiation
D	0045663	biological_process	positive regulation of myoblast differentiation
D	0045944	biological_process	positive regulation of transcription by RNA polymerase II
D	0046323	biological_process	D-glucose import
D	0046326	biological_process	positive regulation of D-glucose import
D	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
D	0048273	molecular_function	mitogen-activated protein kinase p38 binding
D	0048863	biological_process	stem cell differentiation
D	0051146	biological_process	striated muscle cell differentiation
D	0051149	biological_process	positive regulation of muscle cell differentiation
D	0051403	biological_process	stress-activated MAPK cascade
D	0051525	molecular_function	NFAT protein binding
D	0060045	biological_process	positive regulation of cardiac muscle cell proliferation
D	0060348	biological_process	bone development
D	0070935	biological_process	3'-UTR-mediated mRNA stabilization
D	0071222	biological_process	cellular response to lipopolysaccharide
D	0071223	biological_process	cellular response to lipoteichoic acid
D	0071356	biological_process	cellular response to tumor necrosis factor
D	0071479	biological_process	cellular response to ionizing radiation
D	0071493	biological_process	cellular response to UV-B
D	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
D	0090336	biological_process	positive regulation of brown fat cell differentiation
D	0090398	biological_process	cellular senescence
D	0090400	biological_process	stress-induced premature senescence
D	0098586	biological_process	cellular response to virus
D	0098978	cellular_component	glutamatergic synapse
D	0099179	biological_process	regulation of synaptic membrane adhesion
D	0106310	molecular_function	protein serine kinase activity
D	1900015	biological_process	regulation of cytokine production involved in inflammatory response
D	1901741	biological_process	positive regulation of myoblast fusion
D	1904813	cellular_component	ficolin-1-rich granule lumen
D	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
E	0000165	biological_process	MAPK cascade
E	0000166	molecular_function	nucleotide binding
E	0002224	biological_process	toll-like receptor signaling pathway
E	0004672	molecular_function	protein kinase activity
E	0004674	molecular_function	protein serine/threonine kinase activity
E	0004683	molecular_function	calcium/calmodulin-dependent protein kinase activity
E	0005515	molecular_function	protein binding
E	0005516	molecular_function	calmodulin binding
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005813	cellular_component	centrosome
E	0005829	cellular_component	cytosol
E	0006468	biological_process	protein phosphorylation
E	0006691	biological_process	leukotriene metabolic process
E	0006954	biological_process	inflammatory response
E	0006974	biological_process	DNA damage response
E	0009931	molecular_function	calcium-dependent protein serine/threonine kinase activity
E	0010803	biological_process	regulation of tumor necrosis factor-mediated signaling pathway
E	0016301	molecular_function	kinase activity
E	0016740	molecular_function	transferase activity
E	0032496	biological_process	response to lipopolysaccharide
E	0032675	biological_process	regulation of interleukin-6 production
E	0032680	biological_process	regulation of tumor necrosis factor production
E	0032760	biological_process	positive regulation of tumor necrosis factor production
E	0034097	biological_process	response to cytokine
E	0035556	biological_process	intracellular signal transduction
E	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
E	0036064	cellular_component	ciliary basal body
E	0038066	biological_process	p38MAPK cascade
E	0043488	biological_process	regulation of mRNA stability
E	0044351	biological_process	macropinocytosis
E	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
E	0048255	biological_process	mRNA stabilization
E	0048839	biological_process	inner ear development
E	0051019	molecular_function	mitogen-activated protein kinase binding
E	0060907	biological_process	positive regulation of macrophage cytokine production
E	0070062	cellular_component	extracellular exosome
E	0070935	biological_process	3'-UTR-mediated mRNA stabilization
E	0106310	molecular_function	protein serine kinase activity
E	1900034	biological_process	regulation of cellular response to heat
F	0000077	biological_process	DNA damage checkpoint signaling
F	0000165	biological_process	MAPK cascade
F	0000166	molecular_function	nucleotide binding
F	0000902	biological_process	cell morphogenesis
F	0000922	cellular_component	spindle pole
F	0001502	biological_process	cartilage condensation
F	0001525	biological_process	angiogenesis
F	0001649	biological_process	osteoblast differentiation
F	0001890	biological_process	placenta development
F	0002021	biological_process	response to dietary excess
F	0002062	biological_process	chondrocyte differentiation
F	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
F	0004672	molecular_function	protein kinase activity
F	0004674	molecular_function	protein serine/threonine kinase activity
F	0004707	molecular_function	MAP kinase activity
F	0004708	molecular_function	MAP kinase kinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005739	cellular_component	mitochondrion
F	0005829	cellular_component	cytosol
F	0006006	biological_process	glucose metabolic process
F	0006355	biological_process	regulation of DNA-templated transcription
F	0006357	biological_process	regulation of transcription by RNA polymerase II
F	0006366	biological_process	transcription by RNA polymerase II
F	0006468	biological_process	protein phosphorylation
F	0006915	biological_process	apoptotic process
F	0006935	biological_process	chemotaxis
F	0006974	biological_process	DNA damage response
F	0007165	biological_process	signal transduction
F	0007166	biological_process	cell surface receptor signaling pathway
F	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
F	0007519	biological_process	skeletal muscle tissue development
F	0010628	biological_process	positive regulation of gene expression
F	0010831	biological_process	positive regulation of myotube differentiation
F	0016301	molecular_function	kinase activity
F	0016607	cellular_component	nuclear speck
F	0016740	molecular_function	transferase activity
F	0019395	biological_process	fatty acid oxidation
F	0019899	molecular_function	enzyme binding
F	0019903	molecular_function	protein phosphatase binding
F	0030168	biological_process	platelet activation
F	0030278	biological_process	regulation of ossification
F	0030316	biological_process	osteoclast differentiation
F	0031098	biological_process	stress-activated protein kinase signaling cascade
F	0031281	biological_process	positive regulation of cyclase activity
F	0031663	biological_process	lipopolysaccharide-mediated signaling pathway
F	0032495	biological_process	response to muramyl dipeptide
F	0032496	biological_process	response to lipopolysaccharide
F	0032735	biological_process	positive regulation of interleukin-12 production
F	0032868	biological_process	response to insulin
F	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
F	0034774	cellular_component	secretory granule lumen
F	0035331	biological_process	negative regulation of hippo signaling
F	0035556	biological_process	intracellular signal transduction
F	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
F	0035994	biological_process	response to muscle stretch
F	0038066	biological_process	p38MAPK cascade
F	0042307	biological_process	positive regulation of protein import into nucleus
F	0042770	biological_process	signal transduction in response to DNA damage
F	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
F	0045648	biological_process	positive regulation of erythrocyte differentiation
F	0045663	biological_process	positive regulation of myoblast differentiation
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0046323	biological_process	D-glucose import
F	0046326	biological_process	positive regulation of D-glucose import
F	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
F	0048273	molecular_function	mitogen-activated protein kinase p38 binding
F	0048863	biological_process	stem cell differentiation
F	0051146	biological_process	striated muscle cell differentiation
F	0051149	biological_process	positive regulation of muscle cell differentiation
F	0051403	biological_process	stress-activated MAPK cascade
F	0051525	molecular_function	NFAT protein binding
F	0060045	biological_process	positive regulation of cardiac muscle cell proliferation
F	0060348	biological_process	bone development
F	0070935	biological_process	3'-UTR-mediated mRNA stabilization
F	0071222	biological_process	cellular response to lipopolysaccharide
F	0071223	biological_process	cellular response to lipoteichoic acid
F	0071356	biological_process	cellular response to tumor necrosis factor
F	0071479	biological_process	cellular response to ionizing radiation
F	0071493	biological_process	cellular response to UV-B
F	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
F	0090336	biological_process	positive regulation of brown fat cell differentiation
F	0090398	biological_process	cellular senescence
F	0090400	biological_process	stress-induced premature senescence
F	0098586	biological_process	cellular response to virus
F	0098978	cellular_component	glutamatergic synapse
F	0099179	biological_process	regulation of synaptic membrane adhesion
F	0106310	molecular_function	protein serine kinase activity
F	1900015	biological_process	regulation of cytokine production involved in inflammatory response
F	1901741	biological_process	positive regulation of myoblast fusion
F	1904813	cellular_component	ficolin-1-rich granule lumen
F	2000379	biological_process	positive regulation of reactive oxygen species metabolic process
G	0000165	biological_process	MAPK cascade
G	0000166	molecular_function	nucleotide binding
G	0002224	biological_process	toll-like receptor signaling pathway
G	0004672	molecular_function	protein kinase activity
G	0004674	molecular_function	protein serine/threonine kinase activity
G	0004683	molecular_function	calcium/calmodulin-dependent protein kinase activity
G	0005515	molecular_function	protein binding
G	0005516	molecular_function	calmodulin binding
G	0005524	molecular_function	ATP binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005813	cellular_component	centrosome
G	0005829	cellular_component	cytosol
G	0006468	biological_process	protein phosphorylation
G	0006691	biological_process	leukotriene metabolic process
G	0006954	biological_process	inflammatory response
G	0006974	biological_process	DNA damage response
G	0009931	molecular_function	calcium-dependent protein serine/threonine kinase activity
G	0010803	biological_process	regulation of tumor necrosis factor-mediated signaling pathway
G	0016301	molecular_function	kinase activity
G	0016740	molecular_function	transferase activity
G	0032496	biological_process	response to lipopolysaccharide
G	0032675	biological_process	regulation of interleukin-6 production
G	0032680	biological_process	regulation of tumor necrosis factor production
G	0032760	biological_process	positive regulation of tumor necrosis factor production
G	0034097	biological_process	response to cytokine
G	0035556	biological_process	intracellular signal transduction
G	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
G	0036064	cellular_component	ciliary basal body
G	0038066	biological_process	p38MAPK cascade
G	0043488	biological_process	regulation of mRNA stability
G	0044351	biological_process	macropinocytosis
G	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
G	0048255	biological_process	mRNA stabilization
G	0048839	biological_process	inner ear development
G	0051019	molecular_function	mitogen-activated protein kinase binding
G	0060907	biological_process	positive regulation of macrophage cytokine production
G	0070062	cellular_component	extracellular exosome
G	0070935	biological_process	3'-UTR-mediated mRNA stabilization
G	0106310	molecular_function	protein serine kinase activity
G	1900034	biological_process	regulation of cellular response to heat
H	0000077	biological_process	DNA damage checkpoint signaling
H	0000165	biological_process	MAPK cascade
H	0000166	molecular_function	nucleotide binding
H	0000902	biological_process	cell morphogenesis
H	0000922	cellular_component	spindle pole
H	0001502	biological_process	cartilage condensation
H	0001525	biological_process	angiogenesis
H	0001649	biological_process	osteoblast differentiation
H	0001890	biological_process	placenta development
H	0002021	biological_process	response to dietary excess
H	0002062	biological_process	chondrocyte differentiation
H	0002862	biological_process	negative regulation of inflammatory response to antigenic stimulus
H	0004672	molecular_function	protein kinase activity
H	0004674	molecular_function	protein serine/threonine kinase activity
H	0004707	molecular_function	MAP kinase activity
H	0004708	molecular_function	MAP kinase kinase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005739	cellular_component	mitochondrion
H	0005829	cellular_component	cytosol
H	0006006	biological_process	glucose metabolic process
H	0006355	biological_process	regulation of DNA-templated transcription
H	0006357	biological_process	regulation of transcription by RNA polymerase II
H	0006366	biological_process	transcription by RNA polymerase II
H	0006468	biological_process	protein phosphorylation
H	0006915	biological_process	apoptotic process
H	0006935	biological_process	chemotaxis
H	0006974	biological_process	DNA damage response
H	0007165	biological_process	signal transduction
H	0007166	biological_process	cell surface receptor signaling pathway
H	0007178	biological_process	cell surface receptor protein serine/threonine kinase signaling pathway
H	0007519	biological_process	skeletal muscle tissue development
H	0010628	biological_process	positive regulation of gene expression
H	0010831	biological_process	positive regulation of myotube differentiation
H	0016301	molecular_function	kinase activity
H	0016607	cellular_component	nuclear speck
H	0016740	molecular_function	transferase activity
H	0019395	biological_process	fatty acid oxidation
H	0019899	molecular_function	enzyme binding
H	0019903	molecular_function	protein phosphatase binding
H	0030168	biological_process	platelet activation
H	0030278	biological_process	regulation of ossification
H	0030316	biological_process	osteoclast differentiation
H	0031098	biological_process	stress-activated protein kinase signaling cascade
H	0031281	biological_process	positive regulation of cyclase activity
H	0031663	biological_process	lipopolysaccharide-mediated signaling pathway
H	0032495	biological_process	response to muramyl dipeptide
H	0032496	biological_process	response to lipopolysaccharide
H	0032735	biological_process	positive regulation of interleukin-12 production
H	0032868	biological_process	response to insulin
H	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
H	0034774	cellular_component	secretory granule lumen
H	0035331	biological_process	negative regulation of hippo signaling
H	0035556	biological_process	intracellular signal transduction
H	0035924	biological_process	cellular response to vascular endothelial growth factor stimulus
H	0035994	biological_process	response to muscle stretch
H	0038066	biological_process	p38MAPK cascade
H	0042307	biological_process	positive regulation of protein import into nucleus
H	0042770	biological_process	signal transduction in response to DNA damage
H	0043536	biological_process	positive regulation of blood vessel endothelial cell migration
H	0045648	biological_process	positive regulation of erythrocyte differentiation
H	0045663	biological_process	positive regulation of myoblast differentiation
H	0045944	biological_process	positive regulation of transcription by RNA polymerase II
H	0046323	biological_process	D-glucose import
H	0046326	biological_process	positive regulation of D-glucose import
H	0048010	biological_process	vascular endothelial growth factor receptor signaling pathway
H	0048273	molecular_function	mitogen-activated protein kinase p38 binding
H	0048863	biological_process	stem cell differentiation
H	0051146	biological_process	striated muscle cell differentiation
H	0051149	biological_process	positive regulation of muscle cell differentiation
H	0051403	biological_process	stress-activated MAPK cascade
H	0051525	molecular_function	NFAT protein binding
H	0060045	biological_process	positive regulation of cardiac muscle cell proliferation
H	0060348	biological_process	bone development
H	0070935	biological_process	3'-UTR-mediated mRNA stabilization
H	0071222	biological_process	cellular response to lipopolysaccharide
H	0071223	biological_process	cellular response to lipoteichoic acid
H	0071356	biological_process	cellular response to tumor necrosis factor
H	0071479	biological_process	cellular response to ionizing radiation
H	0071493	biological_process	cellular response to UV-B
H	0090090	biological_process	negative regulation of canonical Wnt signaling pathway
H	0090336	biological_process	positive regulation of brown fat cell differentiation
H	0090398	biological_process	cellular senescence
H	0090400	biological_process	stress-induced premature senescence
H	0098586	biological_process	cellular response to virus
H	0098978	cellular_component	glutamatergic synapse
H	0099179	biological_process	regulation of synaptic membrane adhesion
H	0106310	molecular_function	protein serine kinase activity
H	1900015	biological_process	regulation of cytokine production involved in inflammatory response
H	1901741	biological_process	positive regulation of myoblast fusion
H	1904813	cellular_component	ficolin-1-rich granule lumen
H	2000379	biological_process	positive regulation of reactive oxygen species metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue 39G B 401

Chain	Residue
A	GLN369
B	ASP168
B	ALA51
B	LYS53
B	GLU71
B	LEU104
B	THR106
B	MET109
B	GLY110
B	ALA111

---

site_id	AC2
Number of Residues	10
Details	binding site for residue 39G D 401

Chain	Residue
D	ALA51
D	LYS53
D	GLU71
D	LEU75
D	LEU104
D	THR106
D	MET109
D	GLY110
D	ALA111
D	ASP168

---

site_id	AC3
Number of Residues	12
Details	binding site for residue 39G F 401

Chain	Residue
E	GLN369
F	ALA51
F	LYS53
F	GLU71
F	LEU75
F	LEU104
F	THR106
F	MET109
F	GLY110
F	ALA111
F	LEU167
F	ASP168

---

site_id	AC4
Number of Residues	10
Details	binding site for residue 39G H 401

Chain	Residue
G	GLN369
H	ALA51
H	LYS53
H	GLU71
H	LEU75
H	THR106
H	MET109
H	GLY110
H	ALA111
H	ASP168

---

Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDVKpeNLLY

Chain	Residue	Details
A	ILE182-TYR194

---

site_id	PS01351
Number of Residues	104
Details	MAPK MAP kinase signature. FqsiihakrtyRElrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddhvqfliyqilrglkyihsadiih.........RDlKpsnlavnedC

Chain	Residue	Details
B	PHE59-CYS162

---

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGSVCaAfdtktglrv.........AVKK

Chain	Residue	Details
B	VAL30-LYS54
A	LEU70-LYS93

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	144
Details	Region: {"description":"Autoinhibitory helix","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	96
Details	Region: {"description":"p38 MAPK-binding site"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	36
Details	Motif: {"description":"Nuclear export signal (NES)"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Motif: {"description":"Bipartite nuclear localization signal 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Motif: {"description":"Bipartite nuclear localization signal 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	12
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by MAPK14","evidences":[{"source":"PubMed","id":"8846784","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by MAPK14","evidences":[{"source":"PubMed","id":"8846784","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"21131586","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by MAPK14","evidences":[{"source":"PubMed","id":"8846784","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	8
Details	Motif: {"description":"TXY"}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	8
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"21444723","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis","evidences":[{"source":"PubMed","id":"7535770","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis","evidences":[{"source":"PubMed","id":"7535770","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine; by ZAP70","evidences":[{"source":"PubMed","id":"15735648","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---