6TAC

Human NAMPT deletion mutant in complex with nicotinamide mononucleotide, pyrophosphate, and Mg2+

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Nicotinamide phosphoribosyltransferase	polymer	493	55782.0	2	UniProt (P43490) Pfam (PF18127) Pfam (PF04095)	Homo sapiens (Human)	Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin
2	C (A)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
3	D, E, H, I (A, B)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG)
4	F, J (A, B)	BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE	non-polymer		335.2	2	Chemie (NMN)
5	G, K (A, B)	PYROPHOSPHATE	non-polymer		178.0	2	Chemie (PPV)
6	L, M (A, B)	water	water		18.0	1153	Chemie (HOH)

Sequence modifications

A, B: 1 - 481 (UniProt: P43490)

PDB	External Database	Details
Met -11	-	initiating methionine
Arg -10	-	expression tag
Gly -9	-	expression tag
Ser -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
Gly -1	-	expression tag
Ser 0	-	expression tag
-	Lys 42	deletion
-	Lys 43	deletion
-	Thr 44	deletion
-	Glu 45	deletion
-	Asn 46	deletion
-	Ser 47	deletion
-	Lys 48	deletion
-	Leu 49	deletion
-	Arg 50	deletion
-	Lys 51	deletion

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	111564.0
Non-Polymers*	Number of molecules	9
	Total formula weight	1215.7
All*	Total formula weight	112779.7

*Water molecules are not included.