6TAC
Human NAMPT deletion mutant in complex with nicotinamide mononucleotide, pyrophosphate, and Mg2+
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Nicotinamide phosphoribosyltransferase | polymer | 493 | 55782.0 | 2 | UniProt (P43490) Pfam (PF18127) Pfam (PF04095) | Homo sapiens (Human) | Nampt,Pre-B-cell colony-enhancing factor 1,Pre-B cell-enhancing factor,Visfatin |
| 2 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 3 | D, E, H, I (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) PubChem (888) | |||
| 4 | F, J (A, B) | BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE | non-polymer | 335.2 | 2 | Chemie (NMN) PubChem (939) PubChem (9819044) PubChem (44269211) PubChem (177675032) PubChem (46874984) PubChem (14181) PubChem (90476335) PubChem (6093202) PubChem (15737496) PubChem (71750998) PubChem (89516131) PubChem (93605785) PubChem (122587981) PubChem (123929622) PubChem (124350426) PubChem (134694109) PubChem (147327152) PubChem (149999359) PubChem (164745794) PubChem (167012155) PubChem (172887170) | |||
| 5 | G, K (A, B) | PYROPHOSPHATE | non-polymer | 178.0 | 2 | Chemie (PPV) PubChem (1023) | |||
| 6 | L, M (A, B) | water | water | 18.0 | 1153 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 481 (UniProt: P43490)
| PDB | External Database | Details |
|---|---|---|
| Met -11 | - | initiating methionine |
| Arg -10 | - | expression tag |
| Gly -9 | - | expression tag |
| Ser -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| - | Lys 42 | deletion |
| - | Lys 43 | deletion |
| - | Thr 44 | deletion |
| - | Glu 45 | deletion |
| - | Asn 46 | deletion |
| - | Ser 47 | deletion |
| - | Lys 48 | deletion |
| - | Leu 49 | deletion |
| - | Arg 50 | deletion |
| - | Lys 51 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 111564.0 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1215.7 | |
| All* | Total formula weight | 112779.7 |
