6TAC
Human NAMPT deletion mutant in complex with nicotinamide mononucleotide, pyrophosphate, and Mg2+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005125 | molecular_function | cytokine activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006954 | biological_process | inflammatory response |
| A | 0007165 | biological_process | signal transduction |
| A | 0007267 | biological_process | cell-cell signaling |
| A | 0007623 | biological_process | circadian rhythm |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0008286 | biological_process | insulin receptor signaling pathway |
| A | 0009435 | biological_process | NAD+ biosynthetic process |
| A | 0010628 | biological_process | positive regulation of gene expression |
| A | 0032922 | biological_process | circadian regulation of gene expression |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| A | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| A | 0047280 | molecular_function | nicotinamide phosphoribosyltransferase activity |
| A | 0060612 | biological_process | adipose tissue development |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070374 | biological_process | positive regulation of ERK1 and ERK2 cascade |
| A | 1901847 | biological_process | nicotinate metabolic process |
| B | 0005125 | molecular_function | cytokine activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006954 | biological_process | inflammatory response |
| B | 0007165 | biological_process | signal transduction |
| B | 0007267 | biological_process | cell-cell signaling |
| B | 0007623 | biological_process | circadian rhythm |
| B | 0008284 | biological_process | positive regulation of cell population proliferation |
| B | 0008286 | biological_process | insulin receptor signaling pathway |
| B | 0009435 | biological_process | NAD+ biosynthetic process |
| B | 0010628 | biological_process | positive regulation of gene expression |
| B | 0032922 | biological_process | circadian regulation of gene expression |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| B | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| B | 0047280 | molecular_function | nicotinamide phosphoribosyltransferase activity |
| B | 0060612 | biological_process | adipose tissue development |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070374 | biological_process | positive regulation of ERK1 and ERK2 cascade |
| B | 1901847 | biological_process | nicotinate metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 501 |
| Chain | Residue |
| A | PHE113 |
| A | VAL114 |
| A | ARG424 |
| A | ASN469 |
| A | HOH631 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 502 |
| Chain | Residue |
| B | HOH840 |
| A | PPV505 |
| A | HOH837 |
| A | HOH883 |
| B | HOH679 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 503 |
| Chain | Residue |
| A | ASP303 |
| A | NMN504 |
| A | HOH722 |
| B | PPV504 |
| site_id | AC4 |
| Number of Residues | 23 |
| Details | binding site for residue NMN A 504 |
| Chain | Residue |
| A | PHE183 |
| A | ARG186 |
| A | ASP209 |
| A | ARG301 |
| A | ASP303 |
| A | GLY343 |
| A | GLY373 |
| A | GLY374 |
| A | MG503 |
| A | HOH621 |
| A | HOH639 |
| A | HOH651 |
| A | HOH678 |
| A | HOH706 |
| A | HOH750 |
| A | HOH821 |
| A | HOH896 |
| A | HOH898 |
| A | HOH954 |
| B | ASP16 |
| B | TYR18 |
| B | ARG382 |
| B | PPV504 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | binding site for residue PPV A 505 |
| Chain | Residue |
| A | ARG40 |
| A | ARG382 |
| A | LYS390 |
| A | LYS405 |
| A | LYS413 |
| A | MG502 |
| A | HOH814 |
| A | HOH837 |
| A | HOH883 |
| B | ARG186 |
| B | ASP303 |
| B | MG502 |
| B | NMN503 |
| B | HOH661 |
| B | HOH679 |
| B | HOH840 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 501 |
| Chain | Residue |
| A | HOH639 |
| A | HOH821 |
| B | PPV504 |
| B | HOH863 |
| B | HOH919 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 502 |
| Chain | Residue |
| A | PPV505 |
| B | ASP303 |
| B | NMN503 |
| B | HOH661 |
| site_id | AC8 |
| Number of Residues | 23 |
| Details | binding site for residue NMN B 503 |
| Chain | Residue |
| A | TYR18 |
| A | ARG382 |
| A | PPV505 |
| B | PHE183 |
| B | ARG186 |
| B | ASP209 |
| B | ARG301 |
| B | ASP303 |
| B | GLY343 |
| B | GLY373 |
| B | GLY374 |
| B | MG502 |
| B | HOH620 |
| B | HOH626 |
| B | HOH669 |
| B | HOH679 |
| B | HOH684 |
| B | HOH752 |
| B | HOH809 |
| B | HOH840 |
| B | HOH841 |
| B | HOH927 |
| B | HOH948 |
| site_id | AC9 |
| Number of Residues | 16 |
| Details | binding site for residue PPV B 504 |
| Chain | Residue |
| B | HOH863 |
| B | HOH919 |
| A | ARG186 |
| A | ASP303 |
| A | MG503 |
| A | NMN504 |
| A | HOH639 |
| A | HOH722 |
| A | HOH821 |
| B | ARG40 |
| B | ARG382 |
| B | LYS390 |
| B | LYS405 |
| B | LYS413 |
| B | MG501 |
| B | HOH805 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
