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6TAC

Human NAMPT deletion mutant in complex with nicotinamide mononucleotide, pyrophosphate, and Mg2+

Functional Information from GO Data
ChainGOidnamespacecontents
A0005125molecular_functioncytokine activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005759cellular_componentmitochondrial matrix
A0005829cellular_componentcytosol
A0006741biological_processNADP+ biosynthetic process
A0006769biological_processnicotinamide metabolic process
A0006954biological_processinflammatory response
A0007165biological_processsignal transduction
A0007267biological_processcell-cell signaling
A0007623biological_processcircadian rhythm
A0008284biological_processpositive regulation of cell population proliferation
A0008286biological_processinsulin receptor signaling pathway
A0009435biological_processNAD+ biosynthetic process
A0010628biological_processpositive regulation of gene expression
A0016607cellular_componentnuclear speck
A0016740molecular_functiontransferase activity
A0016757molecular_functionglycosyltransferase activity
A0019363biological_processpyridine nucleotide biosynthetic process
A0030054cellular_componentcell junction
A0032922biological_processcircadian regulation of gene expression
A0034355biological_processNAD+ biosynthetic process via the salvage pathway
A0042802molecular_functionidentical protein binding
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0047280molecular_functionnicotinamide phosphoribosyltransferase activity
A0048511biological_processrhythmic process
A0060612biological_processadipose tissue development
A0070062cellular_componentextracellular exosome
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0005125molecular_functioncytokine activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005759cellular_componentmitochondrial matrix
B0005829cellular_componentcytosol
B0006741biological_processNADP+ biosynthetic process
B0006769biological_processnicotinamide metabolic process
B0006954biological_processinflammatory response
B0007165biological_processsignal transduction
B0007267biological_processcell-cell signaling
B0007623biological_processcircadian rhythm
B0008284biological_processpositive regulation of cell population proliferation
B0008286biological_processinsulin receptor signaling pathway
B0009435biological_processNAD+ biosynthetic process
B0010628biological_processpositive regulation of gene expression
B0016607cellular_componentnuclear speck
B0016740molecular_functiontransferase activity
B0016757molecular_functionglycosyltransferase activity
B0019363biological_processpyridine nucleotide biosynthetic process
B0030054cellular_componentcell junction
B0032922biological_processcircadian regulation of gene expression
B0034355biological_processNAD+ biosynthetic process via the salvage pathway
B0042802molecular_functionidentical protein binding
B0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0047280molecular_functionnicotinamide phosphoribosyltransferase activity
B0048511biological_processrhythmic process
B0060612biological_processadipose tissue development
B0070062cellular_componentextracellular exosome
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue GOL A 501
ChainResidue
APHE113
AVAL114
AARG424
AASN469
AHOH631

site_idAC2
Number of Residues5
Detailsbinding site for residue MG A 502
ChainResidue
BHOH840
APPV505
AHOH837
AHOH883
BHOH679

site_idAC3
Number of Residues4
Detailsbinding site for residue MG A 503
ChainResidue
AASP303
ANMN504
AHOH722
BPPV504

site_idAC4
Number of Residues23
Detailsbinding site for residue NMN A 504
ChainResidue
APHE183
AARG186
AASP209
AARG301
AASP303
AGLY343
AGLY373
AGLY374
AMG503
AHOH621
AHOH639
AHOH651
AHOH678
AHOH706
AHOH750
AHOH821
AHOH896
AHOH898
AHOH954
BASP16
BTYR18
BARG382
BPPV504

site_idAC5
Number of Residues16
Detailsbinding site for residue PPV A 505
ChainResidue
AARG40
AARG382
ALYS390
ALYS405
ALYS413
AMG502
AHOH814
AHOH837
AHOH883
BARG186
BASP303
BMG502
BNMN503
BHOH661
BHOH679
BHOH840

site_idAC6
Number of Residues5
Detailsbinding site for residue MG B 501
ChainResidue
AHOH639
AHOH821
BPPV504
BHOH863
BHOH919

site_idAC7
Number of Residues4
Detailsbinding site for residue MG B 502
ChainResidue
APPV505
BASP303
BNMN503
BHOH661

site_idAC8
Number of Residues23
Detailsbinding site for residue NMN B 503
ChainResidue
ATYR18
AARG382
APPV505
BPHE183
BARG186
BASP209
BARG301
BASP303
BGLY343
BGLY373
BGLY374
BMG502
BHOH620
BHOH626
BHOH669
BHOH679
BHOH684
BHOH752
BHOH809
BHOH840
BHOH841
BHOH927
BHOH948

site_idAC9
Number of Residues16
Detailsbinding site for residue PPV B 504
ChainResidue
BHOH863
BHOH919
AARG186
AASP303
AMG503
ANMN504
AHOH639
AHOH722
AHOH821
BARG40
BARG382
BLYS390
BLYS405
BLYS413
BMG501
BHOH805

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsBINDING:
ChainResidueDetails
AILE196
BHIS247
BVAL311
BGLU353
BLEU384
BSER392
ALYS219
AHIS247
AVAL311
AGLU353
ALEU384
ASER392
BILE196
BLYS219

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22223895
ChainResidueDetails
AMET1
BMET1

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455
ChainResidueDetails
AVAL188
BVAL188

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ALEU472
BLEU472

237992

PDB entries from 2025-06-25

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