6T9N
CryoEM structure of human polycystin-2/PKD2 in UDM supplemented with PI(4,5)P2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Polycystin-2 | polymer | 547 | 63986.7 | 4 | UniProt (Q13563) Pfam (PF20519) Pfam (PF00520) Pfam (PF08016) | Homo sapiens (Human) | Autosomal dominant polycystic kidney disease type II protein,Polycystic kidney disease 2 protein,Polycystwin,R48321,Transient receptor potential cation channel subfamily P member 2 |
| 2 | E, F, G, H (E, F, G, H) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 4 | In PDB GlyTouCan (G42666HT) | |||
| 3 | FA, I, QA, V (C, A, D, B) | CHOLESTEROL | non-polymer | 386.7 | 4 | Chemie (CLR) | |||
| 4 | GA, HA, J, K, RA... (C, A, D, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 8 | Chemie (NAG) | |||
| 5 | AA, AB, BA, CA, DA... (B, D, C, A) | UNDECYL-MALTOSIDE | non-polymer | 496.6 | 32 | Chemie (UMQ) | |||
| 6 | U (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) |
Sequence modifications
A, B, C, D: 185 - 723 (UniProt: Q13563)
| PDB | External Database | Details |
|---|---|---|
| Met 184 | - | initiating methionine |
| Ala 724 | - | expression tag |
| Glu 725 | - | expression tag |
| Asn 726 | - | expression tag |
| Leu 727 | - | expression tag |
| Tyr 728 | - | expression tag |
| Phe 729 | - | expression tag |
| Gln 730 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 255946.7 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 1697.6 | |
| Non-Polymers* | Number of molecules | 45 |
| Total formula weight | 19247.2 | |
| All* | Total formula weight | 276891.5 |
