6T6D
Crystal structure of the ACVR1 (ALK2) kinase in complex with the compound M4K2149
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D | Activin receptor type I | polymer | 301 | 34537.6 | 4 | UniProt (Q04771) Pfam (PF00069) In PDB | Homo sapiens (Human) | |
| 2 | A, B, C, D | 2-methoxy-4-[4-methyl-5-(4-piperazin-1-ylphenyl)pyridin-3-yl]benzamide | non-polymer | 402.5 | 4 | Chemie (MM8) | |||
| 3 | A, B, C, D | SULFATE ION | non-polymer | 96.1 | 11 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 30 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 201 - 499 (UniProt: Q04771)
| PDB | External Database | Details |
|---|---|---|
| Ser 199 | - | expression tag |
| Met 200 | - | expression tag |
| Asp 207 | Gln 207 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 138150.5 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 2666.6 | |
| All* | Total formula weight | 140817.2 |
