6T4X
ROR(gamma)t ligand binding domain in complex with 25-hydroxycholesterol and allosteric ligand FM26
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Nuclear receptor ROR-gamma | polymer | 263 | 30514.2 | 1 | UniProt (P51449) Pfam (PF00104) | Homo sapiens (Human) | Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma |
| 2 | B (A) | 25-HYDROXYCHOLESTEROL | non-polymer | 402.7 | 1 | Chemie (HC3) | |||
| 3 | C (A) | 4-[(~{E})-[3-[2-chloranyl-6-(trifluoromethyl)phenyl]-5-(1~{H}-pyrrol-3-yl)-1,2-oxazol-4-yl]methylideneamino]benzoic acid | non-polymer | 459.8 | 1 | Chemie (L3E) | |||
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | E (A) | water | water | 18.0 | 255 | Chemie (HOH) |
Sequence modifications
A: 265 - 507 (UniProt: P51449)
| PDB | External Database | Details |
|---|---|---|
| Gly 245 | - | expression tag |
| Ser 246 | - | expression tag |
| Ser 247 | - | expression tag |
| His 248 | - | expression tag |
| His 249 | - | expression tag |
| His 250 | - | expression tag |
| His 251 | - | expression tag |
| His 252 | - | expression tag |
| His 253 | - | expression tag |
| Ser 254 | - | expression tag |
| Ser 255 | - | expression tag |
| Gly 256 | - | expression tag |
| Leu 257 | - | expression tag |
| Val 258 | - | expression tag |
| Pro 259 | - | expression tag |
| Arg 260 | - | expression tag |
| Gly 261 | - | expression tag |
| Ser 262 | - | expression tag |
| His 263 | - | expression tag |
| Met 264 | - | expression tag |
| His 455 | Cys 455 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30514.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 954.6 | |
| All* | Total formula weight | 31468.7 |
