6T4X

ROR(gamma)t ligand binding domain in complex with 25-hydroxycholesterol and allosteric ligand FM26

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue HC3 A 601

Chain	Residue
A	GLN286
A	CYS320
A	LEU324
A	MET365
A	HIS479
A	LEU483
A	PHE486
A	GOL603
A	HOH810

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site_id	AC2
Number of Residues	16
Details	binding site for residue L3E A 602

Chain	Residue
A	TRP317
A	LEU324
A	THR325
A	GLN329
A	LEU353
A	LYS354
A	MET358
A	VAL480
A	LEU483
A	GLN484
A	ALA496
A	ALA497
A	PHE498
A	TYR502
A	LEU505
A	PHE506

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site_id	AC3
Number of Residues	7
Details	binding site for residue GOL A 603

Chain	Residue
A	GLN286
A	PHE377
A	PHE378
A	GLU379
A	HC3601
A	HOH736
A	HOH882

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