6T4K

ROR(gamma)t ligand binding domain in complex with desmosterol and allosteric ligand MRL871

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Nuclear receptor ROR-gamma	polymer	263	30514.2	1	UniProt (P51449) Pfam (PF00104)	Homo sapiens (Human)	Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma
2	B (A)	desmosterol	non-polymer		384.6	1	Chemie (MHQ)
3	C (A)	4-{1-[2-chloro-6-(trifluoromethyl)benzoyl]-1H-indazol-3-yl}benzoic acid	non-polymer		444.8	1	Chemie (4F1)
4	D, E (A)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5	F (A)	water	water		18.0	71	Chemie (HOH)

Sequence modifications

A: 265 - 507 (UniProt: P51449)

PDB	External Database	Details
Gly 245	-	expression tag
Ser 246	-	expression tag
Ser 247	-	expression tag
His 248	-	expression tag
His 249	-	expression tag
His 250	-	expression tag
His 251	-	expression tag
His 252	-	expression tag
His 253	-	expression tag
Ser 254	-	expression tag
Ser 255	-	expression tag
Gly 256	-	expression tag
Leu 257	-	expression tag
Val 258	-	expression tag
Pro 259	-	expression tag
Arg 260	-	expression tag
Gly 261	-	expression tag
Ser 262	-	expression tag
His 263	-	expression tag
Met 264	-	expression tag
His 455	Cys 455	conflict

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	30514.2
Non-Polymers*	Number of molecules	4
	Total formula weight	1013.6
All*	Total formula weight	31527.8

*Water molecules are not included.