6SYT

Structure of the SMG1-SMG8-SMG9 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	SMG1,Serine/threonine-protein kinase SMG1,SMG1,Serine/threonine-protein kinase SMG1,SMG1,Serine/threonine-protein kinase SMG1,SMG1,Serine/threonine-protein kinase SMG1,SMG1,Serine/threonine-protein kinase SMG1	polymer	3712	401403.9	1	UniProt (Q96Q15) Pfam (PF15785) Pfam (PF00454) Pfam (PF02260) In PDB	Homo sapiens	hSMG-1,61E3.4,Lambda/iota protein kinase C-interacting protein,Lambda-interacting protein,hSMG-1,61E3.4,Lambda/iota protein kinase C-interacting protein,Lambda-interacting protein,hSMG-1,61E3.4,Lambda/iota protein kinase C-interacting protein,Lambda-interacting protein,hSMG-1,61E3.4,Lambda/iota protein kinase C-interacting protein,Lambda-interacting protein,hSMG-1,61E3.4,Lambda/iota protein kinase C-interacting protein,Lambda-interacting protein
2	B	Protein SMG8	polymer	991	109825.8	1	UniProt (Q8ND04) Pfam (PF10220) In PDB	Homo sapiens (Human)	Amplified in breast cancer gene 2 protein,Protein smg-8 homolog
3	C	Protein SMG9	polymer	520	57717.5	1	UniProt (Q9H0W8) In PDB	Homo sapiens (Human)	Protein SMG-9
4	A	INOSITOL HEXAKISPHOSPHATE	non-polymer		660.0	1	Chemie (IHP)
5	C	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	1	Chemie (ATP)
6	C	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)

Sequence modifications

A: -94 - 304 (PDB: 6SYT)
A: 311 - 1638 (UniProt: Q96Q15)

PDB	External Database	Details
Arg 743	Lys 743	conflict

A: 1638 - 1717 (PDB: 6SYT)
A: 1727 - 1978 (UniProt: Q96Q15)
A: 1978 - 2021 (PDB: 6SYT)
A: 2035 - 2056 (UniProt: Q96Q15)
A: 2056 - 2083 (PDB: 6SYT)
A: 2088 - 2232 (UniProt: Q96Q15)
A: 2232 - 2265 (PDB: 6SYT)
A: 2275 - 3661 (UniProt: Q96Q15)

PDB	External Database	Details
Ala 2335	Asp 2335	engineered mutation

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.