6STI
Crystal structure of RXRalpha LBD in complex with LG 100754 and a coactivator peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Retinoic acid receptor RXR-alpha | polymer | 244 | 27269.5 | 1 | UniProt (P19793) Pfam (PF00104) | Homo sapiens (human) | Nuclear receptor subfamily 2 group B member 1,Retinoid X receptor alpha |
| 2 | B (B) | Nuclear receptor coactivator 2 | polymer | 13 | 1579.9 | 1 | UniProt (Q15596) | Homo sapiens (human) | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
| 3 | C (A) | (2E,4E,6Z)-3-methyl-7-(5,5,8,8-tetramethyl-3-propoxy-5,6,7,8-tetrahydronaphthalen-2-yl)octa-2,4,6-trienoic acid | non-polymer | 396.6 | 1 | Chemie (754) | |||
| 4 | D (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 287 | Chemie (HOH) |
Sequence modifications
A: 223 - 462 (UniProt: P19793)
| PDB | External Database | Details |
|---|---|---|
| Gly 219 | - | expression tag |
| Ser 220 | - | expression tag |
| His 221 | - | expression tag |
| Met 222 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28849.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 455.6 | |
| All* | Total formula weight | 29305.0 |
