6SS2
Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0021158
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (AAA) | Arginase-2, mitochondrial | polymer | 339 | 37100.9 | 1 | UniProt (P78540) Pfam (PF00491) | Homo sapiens (Human) | Arginase II,Kidney-type arginase,Non-hepatic arginase,Type II arginase |
| 2 | B (HHH) | Fab C0021158 heavy chain (IgG1) | polymer | 233 | 24647.8 | 1 | Homo sapiens (Human) | ||
| 3 | C (LLL) | Fab C0021158 light chain (IgG1) | polymer | 220 | 23137.5 | 1 | Homo sapiens (Human) | ||
| 4 | BA, CA, D, DA, E... (HHH, AAA, LLL) | GLYCEROL | non-polymer | 92.1 | 20 | Chemie (GOL) | |||
| 5 | Q, R (AAA) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 6 | AA, EA, FA, KA, LA... (AAA, HHH, LLL) | SULFATE ION | non-polymer | 96.1 | 17 | Chemie (SO4) | |||
| 7 | QA, RA, SA (AAA, HHH, LLL) | water | water | 18.0 | 59 | Chemie (HOH) |
Sequence modifications
AAA: 23 - 354 (UniProt: P78540)
| PDB | External Database | Details |
|---|---|---|
| Met 22 | - | initiating methionine |
| His 355 | - | expression tag |
| His 356 | - | expression tag |
| His 357 | - | expression tag |
| His 358 | - | expression tag |
| His 359 | - | expression tag |
| His 360 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 84886.2 | |
| Non-Polymers* | Number of molecules | 39 |
| Total formula weight | 3584.8 | |
| All* | Total formula weight | 88471.0 |
