6SS2

Structure of arginase-2 in complex with the inhibitory human antigen-binding fragment Fab C0021158

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000050	biological_process	urea cycle
AAA	0001657	biological_process	ureteric bud development
AAA	0002250	biological_process	adaptive immune response
AAA	0002376	biological_process	immune system process
AAA	0002829	biological_process	negative regulation of type 2 immune response
AAA	0004053	molecular_function	arginase activity
AAA	0005515	molecular_function	protein binding
AAA	0005737	cellular_component	cytoplasm
AAA	0005739	cellular_component	mitochondrion
AAA	0005759	cellular_component	mitochondrial matrix
AAA	0006525	biological_process	arginine metabolic process
AAA	0006809	biological_process	nitric oxide biosynthetic process
AAA	0006941	biological_process	striated muscle contraction
AAA	0016787	molecular_function	hydrolase activity
AAA	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
AAA	0030145	molecular_function	manganese ion binding
AAA	0032651	biological_process	regulation of interleukin-1 beta production
AAA	0032696	biological_process	negative regulation of interleukin-13 production
AAA	0032700	biological_process	negative regulation of interleukin-17 production
AAA	0032720	biological_process	negative regulation of tumor necrosis factor production
AAA	0045087	biological_process	innate immune response
AAA	0046872	molecular_function	metal ion binding
AAA	0051241	biological_process	negative regulation of multicellular organismal process
AAA	0071641	biological_process	negative regulation of macrophage inflammatory protein 1 alpha production
AAA	0071644	biological_process	negative regulation of chemokine (C-C motif) ligand 4 production
AAA	0071650	biological_process	negative regulation of chemokine (C-C motif) ligand 5 production
AAA	1900425	biological_process	negative regulation of defense response to bacterium
AAA	1903426	biological_process	regulation of reactive oxygen species biosynthetic process
AAA	1905403	biological_process	negative regulation of activated CD8-positive, alpha-beta T cell apoptotic process
AAA	2000562	biological_process	negative regulation of CD4-positive, alpha-beta T cell proliferation
AAA	2000774	biological_process	positive regulation of cellular senescence

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH

Chain	Residue	Details
LLL	TYR192-HIS198
HHH	TYR194-HIS200

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site_id	PS01053
Number of Residues	22
Details	ARGINASE_1 Arginase family signature. SFDIDafdPtlaPAtgtpvvgG

Chain	Residue	Details
AAA	SER249-GLY270

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269|PubMed:12859189, ECO:0007744|PDB:1PQ3, ECO:0007744|PDB:4HZE, ECO:0007744|PDB:4I06, ECO:0007744|PDB:4IE2, ECO:0007744|PDB:4IE3, ECO:0007744|PDB:4IXU, ECO:0007744|PDB:4IXV

Chain	Residue	Details
AAA	HIS120
AAA	ASP143
AAA	HIS145
AAA	ASP147
AAA	SER156
AAA	ASP202
AAA	ASP251
AAA	ASP253
AAA	GLU296

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P53608

Chain	Residue	Details
AAA	THR265

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