6SQP
Crystal structure of Cat MDM2-S429E RING domain homodimer
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | E3 ubiquitin-protein ligase Mdm2 | polymer | 63 | 7152.7 | 1 | UniProt (Q7YRZ8) Pfam (PF13920) In PDB | Felis catus (Cat) | Double minute 2 protein,RING-type E3 ubiquitin transferase Mdm2,p53-binding protein Mdm2 |
2 | B, D | E3 ubiquitin-protein ligase Mdm2 | polymer | 68 | 7720.3 | 2 | UniProt (Q7YRZ8) Pfam (PF13920) In PDB | Felis catus (Cat) | Double minute 2 protein,RING-type E3 ubiquitin transferase Mdm2,p53-binding protein Mdm2 |
3 | C | E3 ubiquitin-protein ligase Mdm2 | polymer | 65 | 7378.9 | 1 | UniProt (Q7YRZ8) Pfam (PF13920) In PDB | Felis catus (Cat) | Double minute 2 protein,RING-type E3 ubiquitin transferase Mdm2,p53-binding protein Mdm2 |
4 | A, B, C, D | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
5 | A, C | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
6 | D | NITRATE ION | non-polymer | 62.0 | 1 | Chemie (NO3) | |||
7 | water | water | 18.0 | 243 | Chemie (HOH) |
Sequence modifications
A: 430 - 491 (UniProt: Q7YRZ8)
B, D: 424 - 491 (UniProt: Q7YRZ8)
C: 427 - 491 (UniProt: Q7YRZ8)
PDB | External Database | Details |
---|---|---|
Glu 429 | - | engineered mutation |
Thr 443 | Gly 443 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Glu 429 | Ser 429 | engineered mutation |
Thr 443 | Gly 443 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Glu 429 | Ser 429 | engineered mutation |
Thr 443 | Gly 443 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 29972.3 | |
Non-Polymers* | Number of molecules | 11 |
Total formula weight | 656.2 | |
All* | Total formula weight | 30628.5 |