6SQP
Crystal structure of Cat MDM2-S429E RING domain homodimer
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005634 | cellular_component | nucleus |
A | 0042802 | molecular_function | identical protein binding |
A | 0043066 | biological_process | negative regulation of apoptotic process |
A | 0051726 | biological_process | regulation of cell cycle |
A | 0061630 | molecular_function | ubiquitin protein ligase activity |
B | 0005634 | cellular_component | nucleus |
B | 0042802 | molecular_function | identical protein binding |
B | 0043066 | biological_process | negative regulation of apoptotic process |
B | 0051726 | biological_process | regulation of cell cycle |
B | 0061630 | molecular_function | ubiquitin protein ligase activity |
C | 0005634 | cellular_component | nucleus |
C | 0042802 | molecular_function | identical protein binding |
C | 0043066 | biological_process | negative regulation of apoptotic process |
C | 0051726 | biological_process | regulation of cell cycle |
C | 0061630 | molecular_function | ubiquitin protein ligase activity |
D | 0005634 | cellular_component | nucleus |
D | 0042802 | molecular_function | identical protein binding |
D | 0043066 | biological_process | negative regulation of apoptotic process |
D | 0051726 | biological_process | regulation of cell cycle |
D | 0061630 | molecular_function | ubiquitin protein ligase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue ZN A 501 |
Chain | Residue |
A | CYS438 |
A | CYS441 |
A | CYS461 |
A | CYS464 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue ZN A 502 |
Chain | Residue |
A | HIS452 |
A | HIS457 |
A | CYS475 |
A | CYS478 |
site_id | AC3 |
Number of Residues | 1 |
Details | binding site for residue CL A 503 |
Chain | Residue |
A | ARG479 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue ZN B 501 |
Chain | Residue |
B | CYS438 |
B | CYS441 |
B | ARG444 |
B | CYS461 |
B | CYS464 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue ZN B 502 |
Chain | Residue |
B | HIS452 |
B | HIS457 |
B | CYS475 |
B | CYS478 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue ZN C 501 |
Chain | Residue |
C | CYS438 |
C | CYS441 |
C | CYS461 |
C | CYS464 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue ZN C 502 |
Chain | Residue |
C | HIS452 |
C | HIS457 |
C | CYS475 |
C | CYS478 |
site_id | AC8 |
Number of Residues | 4 |
Details | binding site for residue ZN D 501 |
Chain | Residue |
D | CYS438 |
D | CYS441 |
D | CYS461 |
D | CYS464 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue ZN D 502 |
Chain | Residue |
D | HIS452 |
D | HIS457 |
D | CYS475 |
D | CYS478 |
site_id | AD1 |
Number of Residues | 2 |
Details | binding site for residue NO3 D 503 |
Chain | Residue |
B | ASN472 |
D | ARG444 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 41 |
Details | ZN_FING: RING-type => ECO:0000255|PROSITE-ProRule:PRU00175 |
Chain | Residue | Details |
C | CYS438-ARG479 | |
D | CYS438-ARG479 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by ATM => ECO:0000250|UniProtKB:Q00987 |
Chain | Residue | Details |
C | GLU429 | |
D | GLU429 |