6SQM
Crystal structure of CREBBP bromodomain complexed with LA36
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | CREB-binding protein | polymer | 119 | 14223.3 | 3 | UniProt (Q92793) Pfam (PF00439) | Homo sapiens (Human) | |
| 2 | D, E, I (A, B, C) | ~{N}-[3-acetamido-5-[(3-methylcinnolin-5-yl)carbamoyl]phenyl]furan-2-carboxamide | non-polymer | 429.4 | 3 | Chemie (LU5) | |||
| 3 | F, G, H (B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 4 | J, K, L (A, B, C) | water | water | 18.0 | 523 | Chemie (HOH) |
Sequence modifications
A, B, C: 1081 - 1197 (UniProt: Q92793)
| PDB | External Database | Details |
|---|---|---|
| Ser 1079 | - | expression tag |
| Met 1080 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 42670.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1474.5 | |
| All* | Total formula weight | 44144.5 |
