6SQC

Crystal structure of complex between nuclear coactivator binding domain of CBP and [1040-1086]ACTR containing alpha-methylated Leu1055 and Leu1076

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Maltose/maltodextrin-binding periplasmic protein,CREB-binding protein	polymer	424	46290.5	1	UniProt (P0AEX9) UniProt (Q92793) Pfam (PF01547) Pfam (PF09030)	Escherichia coli (strain K12)	MMBP,Maltodextrin-binding protein,Maltose-binding protein,MBP
2	B (B)	Nuclear receptor coactivator 3	polymer	47	5131.6	1	UniProt (Q9Y6Q9) Pfam (PF08815)	Homo sapiens	NCoA-3,ACTR,Amplified in breast cancer 1 protein,AIB-1,CBP-interacting protein,pCIP,Class E basic helix-loop-helix protein 42,bHLHe42,Receptor-associated coactivator 3,RAC-3,Steroid receptor coactivator protein 3,SRC-3,Thyroid hormone receptor activator molecule 1,TRAM-1
3	C (C)	alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose	branched		342.3	1	In PDB BIRD (PRD_900001) GlyTouCan (G07411ON)		alpha-maltose
4	D (A)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
5	E, F (A)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
6	G, H (A, B)	water	water		18.0	156	Chemie (HOH)

Sequence modifications

A: 1690 - 2059 (UniProt: P0AEX9)

PDB	External Database	Details
Met 1689	-	initiating methionine
Ala 1771	Asp 108	conflict
Ala 1772	Lys 109	conflict
Ala 1928	Lys 265	conflict
Ala 2048	Glu 385	conflict
Ala 2051	Lys 388	conflict
Ala 2052	Asp 389	conflict
Asn 2056	Arg 393	conflict
Ala 2057	Ile 394	conflict
Ala 2058	Thr 395	conflict
Ala 2059	Lys 396	conflict
Met 2060	-	linker

A: 2061 - 2112 (UniProt: Q92793)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	51422.1
Branched	Number of molecules	1
	Total formula weight	342.3
Non-Polymers*	Number of molecules	3
	Total formula weight	192.9
All*	Total formula weight	51957.3

*Water molecules are not included.