6SP1
KEAP1 IN COMPLEX WITH COMPOUND 6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Kelch-like ECH-associated protein 1 | polymer | 293 | 31951.8 | 2 | UniProt (Q14145) Pfam (PF01344) In PDB | Homo sapiens (Human) | Cytosolic inhibitor of Nrf2,INrf2,Kelch-like protein 19 |
| 2 | A | (1~{S},2~{R})-2-[[(1~{S})-1-[[1,3-bis(oxidanylidene)isoindol-2-yl]methyl]-5-(2-hydroxyethyloxy)-3,4-dihydro-1~{H}-isoquinolin-2-yl]carbonyl]cyclohexane-1-carboxylic acid | non-polymer | 506.5 | 1 | Chemie (LQ8) | |||
| 3 | A, B | ACETATE ION | non-polymer | 59.0 | 15 | Chemie (ACT) | |||
| 4 | water | water | 18.0 | 173 | Chemie (HOH) |
Sequence modifications
A, B: 321 - 609 (UniProt: Q14145)
| PDB | External Database | Details |
|---|---|---|
| Gly 317 | - | expression tag |
| Ser 318 | - | expression tag |
| His 319 | - | expression tag |
| Met 320 | - | expression tag |
| Ala 540 | Glu 540 | conflict |
| Ala 542 | Glu 542 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 63903.5 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 1392.2 | |
| All* | Total formula weight | 65295.8 |
