6SP1

KEAP1 IN COMPLEX WITH COMPOUND 6

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008134	molecular_function	transcription factor binding
A	0016567	biological_process	protein ubiquitination
A	0031463	cellular_component	Cul3-RING ubiquitin ligase complex
B	0008134	molecular_function	transcription factor binding
B	0016567	biological_process	protein ubiquitination
B	0031463	cellular_component	Cul3-RING ubiquitin ligase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue LQ8 A 701

Chain	Residue
A	TYR334
A	TYR572
A	SER602
A	GLY603
A	VAL604
A	ACT703
A	HOH801
A	HOH815
A	HOH822
A	GLY364
A	LEU365
A	ARG380
A	ASN414
A	ARG415
A	GLY462
A	GLY509
A	ALA556

---

site_id	AC2
Number of Residues	5
Details	binding site for residue ACT A 702

Chain	Residue
A	ARG415
A	PHE478
A	ARG483
A	SER508
A	ACT703

---

site_id	AC3
Number of Residues	6
Details	binding site for residue ACT A 703

Chain	Residue
A	TYR525
A	GLN530
A	SER555
A	TYR572
A	LQ8701
A	ACT702

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ACT A 704

Chain	Residue
A	ARG380
A	GLY433
B	GLY433
B	CYS434

---

site_id	AC5
Number of Residues	3
Details	binding site for residue ACT A 705

Chain	Residue
A	ILE435
A	HIS436
A	ARG459

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ACT A 706

Chain	Residue
A	VAL411
A	HIS432
A	ILE435
A	HIS437

---

site_id	AC7
Number of Residues	5
Details	binding site for residue ACT A 707

Chain	Residue
A	ILE421
A	ASP422
A	HIS424
A	TYR426
A	ARG442

---

site_id	AC8
Number of Residues	3
Details	binding site for residue ACT A 708

Chain	Residue
A	MET399
A	TYR473
A	TYR537

---

site_id	AC9
Number of Residues	3
Details	binding site for residue ACT A 709

Chain	Residue
A	LEU339
A	SER340
A	TYR341

---

site_id	AD1
Number of Residues	5
Details	binding site for residue ACT A 710

Chain	Residue
A	LEU471
A	TYR491
A	PRO492
A	GLU493
A	ARG494

---

site_id	AD2
Number of Residues	2
Details	binding site for residue ACT B 701

Chain	Residue
B	ILE435
B	HIS436

---

site_id	AD3
Number of Residues	4
Details	binding site for residue ACT B 702

Chain	Residue
B	TYR491
B	PRO492
B	GLU493
B	ARG494

---

site_id	AD4
Number of Residues	4
Details	binding site for residue ACT B 703

Chain	Residue
B	MET399
B	TYR473
B	TYR491
B	TYR537

---

site_id	AD5
Number of Residues	5
Details	binding site for residue ACT B 704

Chain	Residue
B	VAL411
B	HIS432
B	ILE435
B	HIS437
B	ACT705

---

site_id	AD6
Number of Residues	5
Details	binding site for residue ACT B 705

Chain	Residue
B	VAL411
B	HIS437
B	SER439
B	ACT704
B	HOH849

---

site_id	AD7
Number of Residues	6
Details	binding site for residue ACT B 706

Chain	Residue
A	ASP385
A	GLY386
A	ASN387
B	PHE478
B	ARG483
B	SER508

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	90
Details	Repeat: {"description":"Kelch 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	100
Details	Repeat: {"description":"Kelch 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	92
Details	Repeat: {"description":"Kelch 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	92
Details	Repeat: {"description":"Kelch 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	92
Details	Repeat: {"description":"Kelch 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Sensor for electrophilic agents","evidences":[{"source":"UniProtKB","id":"Q9Z2X8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"S-cGMP-cysteine","evidences":[{"source":"UniProtKB","id":"Q9Z2X8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---