6SMR
A. thaliana serine hydroxymethyltransferase isoform 4 (AtSHMT4) in complex with methotrexate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Serine hydroxymethyltransferase 4 | polymer | 474 | 52052.0 | 4 | UniProt (O23254) Pfam (PF00464) | Arabidopsis thaliana (Mouse-ear cress) | AtSHMT4,Glycine hydroxymethyltransferase 4,Serine methylase 4 |
| 2 | E, J, N, S (A, B, C, D) | [3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-SERINE | non-polymer | 336.2 | 4 | Chemie (PLS) | |||
| 3 | F, H, K, L, M... (A, B, C, D) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 9 | Chemie (EDO) | |||
| 4 | G, I, T (A, B, D) | METHOTREXATE | non-polymer | 454.4 | 3 | Chemie (MTX) | |||
| 5 | P (C) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 6 | V, W, X, Y (A, B, C, D) | water | water | 18.0 | 965 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 1 - 471 (UniProt: O23254)
| PDB | External Database | Details |
|---|---|---|
| Ser -2 | - | expression tag |
| Asn -1 | - | expression tag |
| Ala 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 208208.1 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 3389.0 | |
| All* | Total formula weight | 211597.2 |
