6SM8
Human jak1 kinase domain in complex with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Tyrosine-protein kinase JAK1 | polymer | 302 | 34746.6 | 1 | UniProt (P23458) Pfam (PF07714) In PDB | Homo sapiens (Human) | Janus kinase 1,JAK-1 |
| 2 | B | Tyrosine-protein kinase JAK1 | polymer | 301 | 34689.5 | 1 | UniProt (P23458) Pfam (PF07714) In PDB | Homo sapiens (Human) | Janus kinase 1,JAK-1 |
| 3 | A, B | 2-chloranyl-6-[(3~{S})-3-[(1~{S})-2-cyano-1-[4-(7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]pyrrolidin-1-yl]benzenecarbonitrile | non-polymer | 442.9 | 2 | Chemie (LKT) | |||
| 4 | B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 5 | water | water | 18.0 | 254 | Chemie (HOH) |
Sequence modifications
A: 854 - 1154 (UniProt: P23458)
| PDB | External Database | Details |
|---|---|---|
| Gly 853 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 69436.1 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1009.9 | |
| All* | Total formula weight | 70446.1 |
