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6SM8

Human jak1 kinase domain in complex with inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0004713molecular_functionprotein tyrosine kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
B0004672molecular_functionprotein kinase activity
B0004713molecular_functionprotein tyrosine kinase activity
B0005524molecular_functionATP binding
B0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues20
Detailsbinding site for residue LKT A 1201
ChainResidue
ALEU881
AGLU957
APHE958
ALEU959
AASP1003
AARG1007
AASN1008
ALEU1010
AGLY1020
AASP1021
AHOH1358
AGLY882
AHOH1364
AGLU883
AGLY884
AHIS885
AGLY887
ALYS888
AALA906
ALYS908

site_idAC2
Number of Residues22
Detailsbinding site for residue LKT B 1201
ChainResidue
BLEU881
BGLY882
BGLU883
BGLY884
BHIS885
BPHE886
BGLY887
BLYS888
BVAL889
BALA906
BLYS908
BMET956
BGLU957
BPHE958
BLEU959
BASP1003
BARG1007
BASN1008
BLEU1010
BGLY1020
BASP1021
BHOH1340

site_idAC3
Number of Residues5
Detailsbinding site for residue EDO B 1202
ChainResidue
BASP866
BPRO867
BHIS869
BTYR894
BGLU903

site_idAC4
Number of Residues4
Detailsbinding site for residue EDO B 1203
ChainResidue
BHIS934
BLYS989
BASP992
BTYR993

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues28
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGHFGKVElCrydpegdntgeq......VAVK
ChainResidueDetails
ALEU881-LYS908
BLEU881-LYS908

site_idPS00109
Number of Residues13
DetailsPROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YVHrDLAARNVLV
ChainResidueDetails
ATYR999-VAL1011
BTYR999-VAL1011

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
ChainResidueDetails
BASP1003

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
ChainResidueDetails
BLEU881

site_idSWS_FT_FI3
Number of Residues1
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000305|PubMed:32750333
ChainResidueDetails
BLYS908

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:11909529
ChainResidueDetails
BPTR1034
BPTR1035

221051

PDB entries from 2024-06-12

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