6SLZ
Crystal structure of human ROR gamma LBD in complex with a (quinolinoxymethyl)benzamide inverse agonist
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Nuclear receptor ROR-gamma | polymer | 247 | 28721.3 | 2 | UniProt (P51449) Pfam (PF00104) | Homo sapiens (Human) | Nuclear receptor RZR-gamma,Nuclear receptor subfamily 1 group F member 3,RAR-related orphan receptor C,Retinoid-related orphan receptor-gamma |
| 2 | C, D (A, B) | (2~{S})-1-[2,4-bis(chloranyl)-3-[[2-methyl-4-(trifluoromethyl)quinolin-8-yl]oxymethyl]phenyl]carbonyl-~{N}-methyl-pyrrolidine-2-carboxamide | non-polymer | 540.4 | 2 | Chemie (LK8) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 165 | Chemie (HOH) |
Sequence modifications
A, B: 261 - 507 (UniProt: P51449)
| PDB | External Database | Details |
|---|---|---|
| Gly 261 | Glu 261 | conflict |
| Ser 262 | Ala 262 | conflict |
| His 263 | Pro 263 | conflict |
| Met 264 | Tyr 264 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 57442.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1080.7 | |
| All* | Total formula weight | 58523.3 |
