6SFO
MAPK14 with bound inhibitor SR-318
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Mitogen-activated protein kinase 14 | polymer | 361 | 41395.2 | 1 | UniProt (Q16539) Pfam (PF00069) | Homo sapiens (Human) | MAPK 14,Cytokine suppressive anti-inflammatory drug-binding protein,CSBP,MAP kinase MXI2,MAX-interacting protein 2,Mitogen-activated protein kinase p38 alpha,MAP kinase p38 alpha,Stress-activated protein kinase 2a,SAPK2a |
| 2 | B (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 3 | C (A) | 5-azanyl-~{N}-[[4-(3-cyclohexylpropylcarbamoyl)phenyl]methyl]-1-phenyl-pyrazole-4-carboxamide | non-polymer | 459.6 | 1 | Chemie (LBE) | |||
| 4 | D (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | E (A) | water | water | 18.0 | 215 | Chemie (HOH) |
Sequence modifications
A: 1 - 360 (UniProt: Q16539)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| His 48 | Leu 48 | conflict |
| Ala 263 | Thr 263 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41395.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 574.7 | |
| All* | Total formula weight | 41969.9 |
