6SC2
Structure of the dynein-2 complex; IFT-train bound model
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | O6-alkylguanine-DNA alkyltransferase mutant,DYNC2H1 variant protein,O6-alkylguanine-DNA alkyltransferase mutant,Cytoplasmic dynein 2 heavy chain 1,DYNC2H1 variant protein,DYNC2H1 variant protein,DYNC2H1 variant protein | polymer | 4513 | 507610.2 | 1 | UniProt (E5BBQ0) UniProt (B0I1S0) | Homo sapiens (Human) | |
| 2 | B (B) | O6-alkylguanine-DNA alkyltransferase mutant,DYNC2H1 variant protein,O6-alkylguanine-DNA alkyltransferase mutant,Cytoplasmic dynein 2 heavy chain 1,DYNC2H1 variant protein,DYNC2H1 variant protein,DYNC2H1 variant protein | polymer | 4513 | 504891.3 | 1 | UniProt (E5BBQ0) UniProt (B0I1S0) | Homo sapiens (Human) | |
| 3 | C (C) | WD repeat-containing protein 60 | polymer | 1066 | 122865.2 | 1 | UniProt (Q8WVS4) | Homo sapiens (Human) | |
| 4 | D (D) | WD repeat-containing protein 34 | polymer | 564 | 60768.3 | 1 | UniProt (Q96EX3) Pfam (PF00400) | Homo sapiens (Human) | |
| 5 | E, F (E, F) | Cytoplasmic dynein 2 light intermediate chain 1 | polymer | 351 | 39681.6 | 2 | UniProt (Q8TCX1) Pfam (PF05783) | Homo sapiens (Human) | Dynein 2 light intermediate chain |
| 6 | G, H (G, H) | Dynein light chain roadblock-type 1 | polymer | 96 | 10934.6 | 2 | UniProt (Q9NP97) Pfam (PF03259) | Homo sapiens (Human) | Bithoraxoid-like protein,BLP,Dynein light chain 2A,cytoplasmic,Dynein-associated protein Km23,Roadblock domain-containing protein 1 |
| 7 | I, J, K, L, M... (I, J, K, L, M...) | Dynein light chain 1, cytoplasmic | polymer | 89 | 10381.9 | 6 | UniProt (P63167) Pfam (PF01221) | Homo sapiens (Human) | 8 kDa dynein light chain,DLC8,Dynein light chain LC8-type 1,Protein inhibitor of neuronal nitric oxide synthase,PIN |
| 8 | O, R, S, T, W... (A, B) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 6 | Chemie (ADP) | |||
| 9 | P, U (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 10 | Q, V (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) |
Sequence modifications
A: -204 - -28 (UniProt: E5BBQ0)
A: 2 - 1020 (UniProt: B0I1S0)
A: 1021 - 1276 (PDB: 6SC2)
A: 1277 - 4307 (UniProt: B0I1S0)
B: -204 - -28 (UniProt: E5BBQ0)
B: 2 - 924 (UniProt: B0I1S0)
B: 925 - 1276 (PDB: 6SC2)
B: 1277 - 4307 (UniProt: B0I1S0)
C: 1 - 1066 (UniProt: Q8WVS4)
D: 1 - 536 (UniProt: Q96EX3)
| PDB | External Database | Details |
|---|---|---|
| Gly -205 | - | expression tag |
| Arg -176 | Glu 33 | conflict |
| Pro -27 | - | linker |
| Gly -26 | - | linker |
| Leu -25 | - | linker |
| Gly -24 | - | linker |
| Gly -23 | - | linker |
| Ser -22 | - | linker |
| Leu -21 | - | linker |
| Glu -20 | - | linker |
| Val -19 | - | linker |
| Leu -18 | - | linker |
| Phe -17 | - | linker |
| Gln -16 | - | linker |
| Gly -15 | - | linker |
| Pro -14 | - | linker |
| Asp -13 | - | linker |
| Tyr -12 | - | linker |
| Asp -11 | - | linker |
| Ile -10 | - | linker |
| Pro -9 | - | linker |
| Thr -8 | - | linker |
| Thr -7 | - | linker |
| Leu -6 | - | linker |
| Glu -5 | - | linker |
| Val -4 | - | linker |
| Leu -3 | - | linker |
| Phe -2 | - | linker |
| Gln -1 | - | linker |
| Gly 0 | - | linker |
| Pro 1 | - | linker |
A: 1021 - 1276 (PDB: 6SC2)
A: 1277 - 4307 (UniProt: B0I1S0)
B: -204 - -28 (UniProt: E5BBQ0)
| PDB | External Database | Details |
|---|---|---|
| Gly -205 | - | expression tag |
| Arg -176 | Glu 33 | conflict |
| Pro -27 | - | linker |
| Gly -26 | - | linker |
| Leu -25 | - | linker |
| Gly -24 | - | linker |
| Gly -23 | - | linker |
| Ser -22 | - | linker |
| Leu -21 | - | linker |
| Glu -20 | - | linker |
| Val -19 | - | linker |
| Leu -18 | - | linker |
| Phe -17 | - | linker |
| Gln -16 | - | linker |
| Gly -15 | - | linker |
| Pro -14 | - | linker |
| Asp -13 | - | linker |
| Tyr -12 | - | linker |
| Asp -11 | - | linker |
| Ile -10 | - | linker |
| Pro -9 | - | linker |
| Thr -8 | - | linker |
| Thr -7 | - | linker |
| Leu -6 | - | linker |
| Glu -5 | - | linker |
| Val -4 | - | linker |
| Leu -3 | - | linker |
| Phe -2 | - | linker |
| Gln -1 | - | linker |
| Gly 0 | - | linker |
| Pro 1 | - | linker |
B: 925 - 1276 (PDB: 6SC2)
B: 1277 - 4307 (UniProt: B0I1S0)
C: 1 - 1066 (UniProt: Q8WVS4)
| PDB | External Database | Details |
|---|---|---|
| Lys 225 | Asn 225 | conflict |
| Phe 292 | Ser 292 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Trp 537 | - | expression tag |
| Ser 538 | - | expression tag |
| His 539 | - | expression tag |
| Pro 540 | - | expression tag |
| Gln 541 | - | expression tag |
| Phe 542 | - | expression tag |
| Glu 543 | - | expression tag |
| Lys 544 | - | expression tag |
| Gly 545 | - | expression tag |
| Ser 546 | - | expression tag |
| Ala 547 | - | expression tag |
| Gly 548 | - | expression tag |
| Ser 549 | - | expression tag |
| Ala 550 | - | expression tag |
| Ala 551 | - | expression tag |
| Gly 552 | - | expression tag |
| Ser 553 | - | expression tag |
| Gly 554 | - | expression tag |
| Ala 555 | - | expression tag |
| Gly 556 | - | expression tag |
| Trp 557 | - | expression tag |
| Ser 558 | - | expression tag |
| His 559 | - | expression tag |
| Pro 560 | - | expression tag |
| Gln 561 | - | expression tag |
| Phe 562 | - | expression tag |
| Glu 563 | - | expression tag |
| Lys 564 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 14 |
| Total formula weight | 1359658.8 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 3626.2 | |
| All* | Total formula weight | 1363285.0 |
