6SAJ
Crystal Structure of BRD4(1) bound to inhibitor BUX6 (12)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bromodomain-containing protein 4 | polymer | 127 | 15099.4 | 1 | UniProt (O60885) Pfam (PF00439) | Homo sapiens (Human) | Protein HUNK1 |
| 2 | B, C, D (A) | (R,R)-2,3-BUTANEDIOL | non-polymer | 90.1 | 3 | Chemie (BU3) | |||
| 3 | E (A) | ~{N}-[2-methoxy-5-(2-oxa-6-azaspiro[3.3]heptan-6-ylsulfonyl)phenyl]-3-methyl-4-oxidanylidene-5,6,7,8-tetrahydro-2~{H}-cyclohepta[c]pyrrole-1-carboxamide | non-polymer | 473.5 | 1 | Chemie (L2Z) | |||
| 4 | F (A) | water | water | 18.0 | 159 | Chemie (HOH) |
Sequence modifications
A: 44 - 168 (UniProt: O60885)
| PDB | External Database | Details |
|---|---|---|
| Ser 42 | - | expression tag |
| Met 43 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 15099.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 743.9 | |
| All* | Total formula weight | 15843.3 |
