6S8L
Structure, Thermodynamics, and Kinetics of Plinabulin Binding to two Tubulin Isotypes
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tubulin alpha-1B chain | polymer | 451 | 50204.4 | 1 | UniProt (P68363) Pfam (PF00091) Pfam (PF03953) | Homo sapiens (Human) | Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain |
| 2 | B (B) | Tubulin beta-3 chain | polymer | 450 | 50481.5 | 1 | UniProt (Q13509) Pfam (PF00091) Pfam (PF03953) | Homo sapiens (Human) | Tubulin beta-4 chain,Tubulin beta-III |
| 3 | C (F) | Designed ankyrin repeat protein (DARPIN) D1 | polymer | 157 | 16662.9 | 1 | synthetic construct | ||
| 4 | D (A) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 5 | E, H (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 6 | F (B) | (3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)methylidene]piperazine-2,5-dione | non-polymer | 336.4 | 1 | Chemie (PN6) | |||
| 7 | G (B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 8 | I, J, K (A, B, F) | water | water | 18.0 | 787 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 117348.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1351.4 | |
| All* | Total formula weight | 118700.2 |
