6S8L
Structure, Thermodynamics, and Kinetics of Plinabulin Binding to two Tubulin Isotypes
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000226 | biological_process | microtubule cytoskeleton organization |
A | 0000278 | biological_process | mitotic cell cycle |
A | 0003725 | molecular_function | double-stranded RNA binding |
A | 0003924 | molecular_function | GTPase activity |
A | 0005198 | molecular_function | structural molecule activity |
A | 0005200 | molecular_function | structural constituent of cytoskeleton |
A | 0005515 | molecular_function | protein binding |
A | 0005525 | molecular_function | GTP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005856 | cellular_component | cytoskeleton |
A | 0005874 | cellular_component | microtubule |
A | 0005881 | cellular_component | cytoplasmic microtubule |
A | 0007017 | biological_process | microtubule-based process |
A | 0015630 | cellular_component | microtubule cytoskeleton |
A | 0016787 | molecular_function | hydrolase activity |
A | 0030705 | biological_process | cytoskeleton-dependent intracellular transport |
A | 0031625 | molecular_function | ubiquitin protein ligase binding |
A | 0051301 | biological_process | cell division |
A | 0071353 | biological_process | cellular response to interleukin-4 |
B | 0000226 | biological_process | microtubule cytoskeleton organization |
B | 0000278 | biological_process | mitotic cell cycle |
B | 0003924 | molecular_function | GTPase activity |
B | 0005200 | molecular_function | structural constituent of cytoskeleton |
B | 0005515 | molecular_function | protein binding |
B | 0005525 | molecular_function | GTP binding |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0005856 | cellular_component | cytoskeleton |
B | 0005874 | cellular_component | microtubule |
B | 0007017 | biological_process | microtubule-based process |
B | 0007411 | biological_process | axon guidance |
B | 0015630 | cellular_component | microtubule cytoskeleton |
B | 0030027 | cellular_component | lamellipodium |
B | 0030175 | cellular_component | filopodium |
B | 0030182 | biological_process | neuron differentiation |
B | 0030424 | cellular_component | axon |
B | 0030425 | cellular_component | dendrite |
B | 0030426 | cellular_component | growth cone |
B | 0038007 | biological_process | netrin-activated signaling pathway |
B | 0042277 | molecular_function | peptide binding |
B | 0042995 | cellular_component | cell projection |
B | 0043025 | cellular_component | neuronal cell body |
B | 0045171 | cellular_component | intercellular bridge |
B | 0046872 | molecular_function | metal ion binding |
B | 0070062 | cellular_component | extracellular exosome |
B | 0071944 | cellular_component | cell periphery |
B | 0072686 | cellular_component | mitotic spindle |
B | 1990791 | biological_process | dorsal root ganglion development |
B | 1990890 | molecular_function | netrin receptor binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 27 |
Details | binding site for residue GTP A 501 |
Chain | Residue |
A | GLY10 |
A | GLY143 |
A | GLY144 |
A | THR145 |
A | GLY146 |
A | ILE171 |
A | VAL177 |
A | GLU183 |
A | ASN206 |
A | TYR224 |
A | ASN228 |
A | GLN11 |
A | ILE231 |
A | MG502 |
A | HOH669 |
A | HOH721 |
A | HOH760 |
A | HOH776 |
A | HOH810 |
B | LYS254 |
A | ALA12 |
A | GLN15 |
A | ASP98 |
A | ALA99 |
A | ALA100 |
A | ASN101 |
A | SER140 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue MG A 502 |
Chain | Residue |
A | GTP501 |
A | HOH669 |
A | HOH696 |
A | HOH721 |
A | HOH810 |
site_id | AC3 |
Number of Residues | 15 |
Details | binding site for residue PN6 B 501 |
Chain | Residue |
B | TYR52 |
B | ASN167 |
B | GLU200 |
B | TYR202 |
B | VAL238 |
B | THR239 |
B | SER241 |
B | LEU242 |
B | LEU248 |
B | LEU252 |
B | LEU255 |
B | ALA316 |
B | THR317 |
B | ILE378 |
B | HOH623 |
site_id | AC4 |
Number of Residues | 22 |
Details | binding site for residue GDP B 502 |
Chain | Residue |
B | GLY10 |
B | GLN11 |
B | CYS12 |
B | GLN15 |
B | SER140 |
B | GLY143 |
B | GLY144 |
B | THR145 |
B | GLY146 |
B | VAL177 |
B | GLU183 |
B | ASN206 |
B | TYR224 |
B | ASN228 |
B | MG503 |
B | HOH601 |
B | HOH602 |
B | HOH650 |
B | HOH656 |
B | HOH661 |
B | HOH694 |
B | HOH725 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue MG B 503 |
Chain | Residue |
B | GDP502 |
B | HOH602 |
B | HOH650 |
B | HOH693 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000305|PubMed:34996871, ECO:0000305|PubMed:35482892, ECO:0007744|PDB:7SJ7, ECO:0007744|PDB:7Z6S |
Chain | Residue | Details |
B | GLY144 | |
B | THR145 | |
B | GLY146 | |
B | ASN206 | |
B | ASN228 | |
B | GLN11 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P68363 |
Chain | Residue | Details |
A | GLU71 | |
A | SER140 | |
A | GLY144 | |
A | THR145 | |
A | THR179 | |
A | ASN206 | |
A | ASN228 | |
B | GLU71 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000305|PubMed:34996871, ECO:0007744|PDB:7SJ7 |
Chain | Residue | Details |
B | SER140 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:16371510 |
Chain | Residue | Details |
B | SER174 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:Q2T9S0 |
Chain | Residue | Details |
A | SER232 | |
B | GLU448 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q2T9S0 |
Chain | Residue | Details |
B | SER454 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | MOD_RES: Omega-N-methylarginine => ECO:0000269|Ref.6 |
Chain | Residue | Details |
A | ARG339 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P68373 |
Chain | Residue | Details |
A | SER439 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | MOD_RES: 5-glutamyl polyglutamate => ECO:0000269|PubMed:32747782 |
Chain | Residue | Details |
A | GLU443 |
site_id | SWS_FT_FI10 |
Number of Residues | 1 |
Details | MOD_RES: 5-glutamyl polyglutamate => ECO:0000250|UniProtKB:P68369 |
Chain | Residue | Details |
A | GLU445 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | MOD_RES: 3'-nitrotyrosine => ECO:0000269|PubMed:10339593 |
Chain | Residue | Details |
A | TYR451 |
site_id | SWS_FT_FI12 |
Number of Residues | 3 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) |
Chain | Residue | Details |
A | LYS326 | |
A | LYS370 |