6S64
Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Transcriptional enhancer factor TEF-4 | polymer | 240 | 27489.1 | 2 | UniProt (Q15562) Pfam (PF17725) | Homo sapiens (Human) | TEA domain family member 2,TEAD-2 |
| 2 | C (A) | MYRISTIC ACID | non-polymer | 228.4 | 1 | Chemie (MYR) | |||
| 3 | D (B) | PALMITIC ACID | non-polymer | 256.4 | 1 | Chemie (PLM) | |||
| 4 | E (B) | 3-[3-(3,4-dichlorophenyl)-4-[(phenylmethyl)carbamoyl]pyrazol-1-yl]propanoic acid | non-polymer | 418.3 | 1 | Chemie (KXE) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A, B: 217 - 447 (UniProt: Q15562)
| PDB | External Database | Details |
|---|---|---|
| Met 216 | - | initiating methionine |
| Val 448 | - | expression tag |
| Glu 449 | - | expression tag |
| His 450 | - | expression tag |
| His 451 | - | expression tag |
| His 452 | - | expression tag |
| His 453 | - | expression tag |
| His 454 | - | expression tag |
| His 455 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 54978.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 903.1 | |
| All* | Total formula weight | 55881.3 |
