6S64
Crystal structure of hTEAD2 in complex with a trisubstituted pyrazole inhibitor
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue MYR A 501 |
| Chain | Residue |
| A | PHE233 |
| A | SER345 |
| A | LYS357 |
| A | PRO378 |
| A | MET379 |
| A | CYS380 |
| A | ILE408 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue KXE B 502 |
| Chain | Residue |
| B | SER349 |
| B | VAL354 |
| B | TYR382 |
| A | LYS352 |
| A | TYR397 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide PLM B 501 and CYS B 380 |
| Chain | Residue |
| B | VAL252 |
| B | VAL355 |
| B | LYS357 |
| B | PRO378 |
| B | MET379 |
| B | GLU381 |
| B | TYR382 |
| B | LEU383 |
| B | VAL384 |
| B | LEU387 |
| B | LEU403 |
| B | PHE428 |
