6S3Q
Structure of human excitatory amino acid transporter 3 (EAAT3) in complex with TFB-TBOA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Excitatory amino acid transporter 3 | polymer | 487 | 53252.9 | 3 | UniProt (P43005) Pfam (PF00375) | Homo sapiens (Human) | Excitatory amino-acid carrier 1,Neuronal and epithelial glutamate transporter,Sodium-dependent glutamate/aspartate transporter 3,Solute carrier family 1 member 1 |
| 2 | D, L, S (A, B, C) | (2~{S},3~{S})-2-azanyl-3-[[3-[[4-(trifluoromethyl)phenyl]carbonylamino]phenyl]methoxy]butanedioic acid | non-polymer | 426.3 | 3 | Chemie (7O9) PubChem (52941382) PubChem (71437906) PubChem (169224283) | |||
| 3 | E, M, T (A, B, C) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 3 | Chemie (Y01) PubChem (65082) PubChem (363416) PubChem (500055) PubChem (13301926) PubChem (13301927) PubChem (16219150) PubChem (22210610) PubChem (45489984) PubChem (57163942) PubChem (89891013) PubChem (99567468) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (11969853) PubChem (137392566) PubChem (137496323) PubChem (155804219) PubChem (169132514) PubChem (60078761) PubChem (73440805) PubChem (99567469) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (124914595) PubChem (124914596) PubChem (131705526) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (154929912) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) | |||
| 4 | F, G, H, I, J... (A, B, C) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 15 | Chemie (PC1) PubChem (65146) PubChem (94190) PubChem (10417837) |
Sequence modifications
A, B, C: 1 - 480 (UniProt: P43005)
| PDB | External Database | Details |
|---|---|---|
| Arg 42 | Ser 42 | engineered mutation |
| Val 92 | Leu 92 | engineered mutation |
| Ala 481 | - | expression tag |
| Glu 482 | - | expression tag |
| Asn 483 | - | expression tag |
| Leu 484 | - | expression tag |
| Tyr 485 | - | expression tag |
| Phe 486 | - | expression tag |
| Gln 487 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 159758.6 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 14591.4 | |
| All* | Total formula weight | 174350.0 |
