6RZB
Cryo-EM structure of mouse cytoplasmic dynein-1 microtubule binding domain bound to microtubules
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tubulin alpha-1B chain | polymer | 437 | 48679.1 | 1 | UniProt (Q2XVP4) Pfam (PF00091) Pfam (PF03953) | Sus scrofa (Pig) | Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain |
| 2 | B (B) | Tubulin beta chain | polymer | 426 | 47825.9 | 1 | UniProt (P02554) Pfam (PF00091) Pfam (PF03953) | Sus scrofa (Pig) | Beta-tubulin |
| 3 | C (C) | MKIAA0325 protein | polymer | 149 | 16893.6 | 1 | UniProt (Q80U36) Pfam (PF12777) UniProt (by SIFTS) (Q9JHU4) | Mus musculus (Mouse) | |
| 4 | D (A) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 5 | E (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | F (B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 7 | G (B) | TAXOL | non-polymer | 853.9 | 1 | Chemie (TA1) |
Sequence modifications
A: 1 - 437 (UniProt: Q2XVP4)
C: 3270 - 3418 (UniProt: Q80U36)
| PDB | External Database | Details |
|---|---|---|
| Thr 340 | Ser 340 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 3323 | Cys 678 | engineered mutation |
| Ala 3387 | Cys 742 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 113398.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1844.6 | |
| All* | Total formula weight | 115243.1 |
