6RZB
Cryo-EM structure of mouse cytoplasmic dynein-1 microtubule binding domain bound to microtubules
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tubulin alpha-1B chain | polymer | 437 | 48679.1 | 1 | UniProt (Q2XVP4) Pfam (PF00091) Pfam (PF03953) | Sus scrofa (Pig) | Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain |
| 2 | B (B) | Tubulin beta chain | polymer | 426 | 47825.9 | 1 | UniProt (P02554) Pfam (PF00091) Pfam (PF03953) | Sus scrofa (Pig) | Beta-tubulin |
| 3 | C (C) | MKIAA0325 protein | polymer | 149 | 16893.6 | 1 | UniProt (Q80U36) Pfam (PF12777) UniProt (by SIFTS) (Q9JHU4) | Mus musculus (Mouse) | |
| 4 | D (A) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 5 | E (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 6 | F (B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 7 | G (B) | TAXOL | non-polymer | 853.9 | 1 | Chemie (TA1) PubChem (16757828) PubChem (16760674) PubChem (21458255) PubChem (23307219) PubChem (23412627) PubChem (23636632) PubChem (24848897) PubChem (24867246) PubChem (16760177) PubChem (16742549) PubChem (21733096) PubChem (23307242) PubChem (23307253) PubChem (23307913) PubChem (24754091) PubChem (24207713) PubChem (24791027) PubChem (25200067) PubChem (42613129) PubChem (42620039) PubChem (44155032) PubChem (44276363) PubChem (44279927) PubChem (44335735) PubChem (44291178) PubChem (44328863) PubChem (44342632) PubChem (44356895) PubChem (44378736) PubChem (45489039) PubChem (46782671) PubChem (71209844) PubChem (53313247) PubChem (53298534) PubChem (54259297) PubChem (54259299) PubChem (57489669) PubChem (57999380) PubChem (58460861) PubChem (58777027) PubChem (58798493) PubChem (58596717) PubChem (59048611) PubChem (59042813) PubChem (58877402) PubChem (44323108) PubChem (44356961) PubChem (44403716) PubChem (60005248) PubChem (59873251) PubChem (59914794) PubChem (59919147) PubChem (60123436) PubChem (60011010) PubChem (60147315) PubChem (66795656) PubChem (14060298) PubChem (46781469) PubChem (176586897) PubChem (177678861) PubChem (36314) PubChem (60915) PubChem (177409) PubChem (184492) PubChem (70801836) PubChem (70842048) PubChem (70848451) PubChem (70856170) PubChem (441276) PubChem (73707502) PubChem (73759704) PubChem (89493063) PubChem (89847578) PubChem (90057663) PubChem (91122402) PubChem (91885464) PubChem (49868078) PubChem (5317123) PubChem (5321715) PubChem (101920282) PubChem (5352019) PubChem (121459571) PubChem (122361554) PubChem (6604028) PubChem (6604616) PubChem (6604814) PubChem (6713921) PubChem (6915727) PubChem (124747272) PubChem (124893098) PubChem (9875988) PubChem (54259298) PubChem (126968948) PubChem (129395998) PubChem (129627423) PubChem (10748131) PubChem (132517454) PubChem (11320430) PubChem (11354895) PubChem (134368714) PubChem (134972678) PubChem (137705323) PubChem (138106885) PubChem (140731501) PubChem (140512017) PubChem (146034004) PubChem (153289350) PubChem (154037993) PubChem (57908851) PubChem (57946364) PubChem (155982214) PubChem (159121804) PubChem (160053861) PubChem (159716711) PubChem (160171678) PubChem (160585530) PubChem (163077211) PubChem (163077212) PubChem (163077209) PubChem (163284947) PubChem (58803237) PubChem (168322423) PubChem (169917882) PubChem (171036874) PubChem (175758871) PubChem (59844545) PubChem (59904698) PubChem (60123443) PubChem (70943371) PubChem (71096818) PubChem (73759783) PubChem (101598423) PubChem (118528174) PubChem (4666) PubChem (124747271) PubChem (124747273) PubChem (124747274) PubChem (5460441) PubChem (126761000) PubChem (9854162) PubChem (9897470) PubChem (10033513) PubChem (10485732) PubChem (11506104) PubChem (11828953) PubChem (14060299) PubChem (14060304) PubChem (14060306) PubChem (14060309) PubChem (15983941) PubChem (133052515) PubChem (133640187) PubChem (134715514) PubChem (143890766) PubChem (152743329) PubChem (154828192) PubChem (144453087) PubChem (160585532) PubChem (163077210) PubChem (163077213) PubChem (163077214) PubChem (163077215) PubChem (165084161) PubChem (166711459) PubChem (167423928) PubChem (170014955) PubChem (170362150) |
Sequence modifications
A: 1 - 437 (UniProt: Q2XVP4)
C: 3270 - 3418 (UniProt: Q80U36)
| PDB | External Database | Details |
|---|---|---|
| Thr 340 | Ser 340 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 3323 | Cys 678 | engineered mutation |
| Ala 3387 | Cys 742 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 113398.5 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1844.6 | |
| All* | Total formula weight | 115243.1 |
