6RZA

Cryo-EM structure of the human inner arm dynein DNAH7 microtubule binding domain bound to microtubules

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	X	Cytoplasmic dynein 1 heavy chain 1,Dynein heavy chain 7, axonemal,Cytoplasmic dynein 1 heavy chain 1	polymer	163	18133.2	1	UniProt (Q9JHU4) UniProt (Q8WXX0) Pfam (PF12777) In PDB	Mus musculus (Mouse)	Cytoplasmic dynein heavy chain 1,Dynein heavy chain,cytosolic,Axonemal beta dynein heavy chain 7,Ciliary dynein heavy chain 7,Dynein heavy chain-like protein 2,hDHC2,Cytoplasmic dynein heavy chain 1,Dynein heavy chain,cytosolic
2	A, C	Tubulin alpha-1B chain	polymer	437	48679.1	2	UniProt (Q2XVP4) Pfam (PF00091) Pfam (PF03953) In PDB	Sus scrofa (Pig)	Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain
3	B, D	Tubulin beta chain	polymer	426	47825.9	2	UniProt (P02554) Pfam (PF00091) Pfam (PF03953) In PDB	Sus scrofa (Pig)	Beta-tubulin
4	A, C	GUANOSINE-5'-TRIPHOSPHATE	non-polymer		523.2	2	Chemie (GTP)
5	A, C	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
6	B, D	GUANOSINE-5'-DIPHOSPHATE	non-polymer		443.2	2	Chemie (GDP)
7	B, D	TAXOL	non-polymer		853.9	2	Chemie (TA1)

Sequence modifications

X: 70 - 84 (UniProt: Q9JHU4)
X: 85 - 223 (UniProt: Q8WXX0)
X: 224 - 232 (UniProt: Q9JHU4)
A, C: 1 - 437 (UniProt: Q2XVP4)

PDB	External Database	Details
Thr 340	Ser 340	conflict

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	211143.0
Non-Polymers*	Number of molecules	8
	Total formula weight	3689.2
All*	Total formula weight	214832.2

*Water molecules are not included.