Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6RZA

Cryo-EM structure of the human inner arm dynein DNAH7 microtubule binding domain bound to microtubules

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0003924	molecular_function	GTPase activity
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0007017	biological_process	microtubule-based process
A	0015630	cellular_component	microtubule cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0003924	molecular_function	GTPase activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0007017	biological_process	microtubule-based process
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000278	biological_process	mitotic cell cycle
C	0003924	molecular_function	GTPase activity
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0007017	biological_process	microtubule-based process
C	0015630	cellular_component	microtubule cytoskeleton
C	0016787	molecular_function	hydrolase activity
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0000226	biological_process	microtubule cytoskeleton organization
D	0000278	biological_process	mitotic cell cycle
D	0003924	molecular_function	GTPase activity
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0007017	biological_process	microtubule-based process
D	0046872	molecular_function	metal ion binding
X	0007018	biological_process	microtubule-based movement
X	0008569	molecular_function	minus-end-directed microtubule motor activity
X	0030286	cellular_component	dynein complex
X	0045505	molecular_function	dynein intermediate chain binding
X	0051959	molecular_function	dynein light intermediate chain binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	binding site for residue GTP A 501

Chain	Residue
A	GLY10
A	ASN101
A	SER140
A	GLY143
A	GLY144
A	THR145
A	GLY146
A	ILE171
A	THR179
A	ASN206
A	TYR224
A	GLN11
A	LEU227
A	ASN228
A	MG502
B	LYS252
A	ALA12
A	GLN15
A	ASP69
A	GLU71
A	ASP98
A	ALA99
A	ALA100

site_id	AC2
Number of Residues	3
Details	binding site for residue MG A 502

Chain	Residue
A	GLN11
A	GLU71
A	GTP501

site_id	AC3
Number of Residues	13
Details	binding site for residue GDP B 501

Chain	Residue
B	GLY10
B	GLN11
B	CYS12
B	GLN15
B	ASN99
B	GLY141
B	GLY142
B	THR143
B	ASP177
B	GLU181
B	ASN204
B	TYR222
B	ASN226

site_id	AC4
Number of Residues	12
Details	binding site for residue TA1 B 502

Chain	Residue
B	GLU22
B	ASP26
B	ASP224
B	HIS227
B	LEU228
B	ALA231
B	PRO272
B	THR274
B	ARG318
B	PRO358
B	ARG359
B	LEU361

site_id	AC5
Number of Residues	23
Details	binding site for residue GTP C 501

Chain	Residue
C	GLY10
C	GLN11
C	ALA12
C	GLN15
C	ASP69
C	GLU71
C	ASP98
C	ALA99
C	ALA100
C	ASN101
C	SER140
C	GLY143
C	GLY144
C	THR145
C	GLY146
C	ILE171
C	THR179
C	ASN206
C	TYR224
C	LEU227
C	ASN228
C	MG502
D	LYS252

site_id	AC6
Number of Residues	3
Details	binding site for residue MG C 502

Chain	Residue
C	GLN11
C	GLU71
C	GTP501

site_id	AC7
Number of Residues	13
Details	binding site for residue GDP D 501

Chain	Residue
D	GLY10
D	GLN11
D	CYS12
D	GLN15
D	ASN99
D	GLY141
D	GLY142
D	THR143
D	ASP177
D	GLU181
D	ASN204
D	TYR222
D	ASN226

site_id	AC8
Number of Residues	13
Details	binding site for residue TA1 D 502

Chain	Residue
D	ARG318
D	PRO358
D	ARG359
D	LEU361
D	GLU22
D	ASP26
D	ASP224
D	HIS227
D	LEU228
D	ALA231
D	PRO272
D	THR274
D	GLN279

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
B	GLY140-GLY146
A	GLY142-GLY148

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
B	MET1-ILE4

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	14
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q13509

Chain	Residue	Details
B	GLN11
D	GLY142
D	THR143
D	GLY144
D	ASN204
D	ASN226
B	SER138
B	GLY142
B	THR143
B	GLY144
B	ASN204
B	ASN226
D	GLN11
D	SER138

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P68363

Chain	Residue	Details
B	GLU69
C	GLU71
C	SER140
C	GLY144
C	THR145
C	THR179
C	ASN206
C	ASN228
D	GLU69
A	SER140
A	GLY144
A	THR145
A	THR179
A	ASN206
A	ASN228
C	GLN11

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P99024

Chain	Residue	Details
B	SER40
D	SER40

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250\|UniProtKB:P99024

Chain	Residue	Details
B	LYS58
D	LYS58
C	SER48
C	SER232

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine; by CDK1 => ECO:0000250\|UniProtKB:Q13885

Chain	Residue	Details
B	SER172
D	SER172

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:P07437

Chain	Residue	Details
B	THR285
B	THR290
D	THR285
D	THR290

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250\|UniProtKB:P07437

Chain	Residue	Details
B	ARG318
D	ARG318
A	LYS370
C	LYS326
C	LYS370

site_id	SWS_FT_FI8
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250\|UniProtKB:P07437

Chain	Residue	Details
B	LYS58
D	LYS58

site_id	SWS_FT_FI9
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250\|UniProtKB:P07437

Chain	Residue	Details
B	LYS324
D	LYS324

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)