6RZ5

XFEL crystal structure of the human cysteinyl leukotriene receptor 1 in complex with zafirlukast

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Cysteinyl leukotriene receptor 1,Soluble cytochrome b562,Cysteinyl leukotriene receptor 1	polymer	423	47927.1	2	UniProt (Q9Y271) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361)	Homo sapiens (Human)	CysLTR1,Cysteinyl leukotriene D4 receptor,LTD4 receptor,G-protein coupled receptor HG55,HMTMF81,Cytochrome b-562,CysLTR1,Cysteinyl leukotriene D4 receptor,LTD4 receptor,G-protein coupled receptor HG55,HMTMF81
2	C, QA, Y (A, B)	zafirlukast	non-polymer		575.7	3	Chemie (ZLK)
3	AA, BA, CA, D, DA... (B, A)	(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate	non-polymer		356.5	17	Chemie (OLC)
4	IA, JA, KA, L, LA... (B, A)	OLEIC ACID	non-polymer		282.5	19	Chemie (OLA)
5	W (A)	PENTAETHYLENE GLYCOL	non-polymer		238.3	1	Chemie (1PE)
6	RA, X (B, A)	SODIUM ION	non-polymer		23.0	2	Chemie (NA)
7	SA, TA (A, B)	water	water		18.0	10	Chemie (HOH)

Sequence modifications

A, B: 1 - 222 (UniProt: Q9Y271)

PDB	External Database	Details
Gly -2	-	expression tag
Gly -1	-	expression tag
Thr 0	-	expression tag

A, B: 1001 - 1105 (UniProt: P0ABE7)

PDB	External Database	Details
Trp 1007	Met 29	conflict
Ile 1102	His 124	conflict
Leu 1106	-	linker
Ser	-	linker
Gly	-	linker

A, B: null - 311 (UniProt: Q9Y271)

PDB	External Database	Details
Ser 1000	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	95854.2
Non-Polymers*	Number of molecules	42
	Total formula weight	13439.2
All*	Total formula weight	109293.4

*Water molecules are not included.