6RZ5
XFEL crystal structure of the human cysteinyl leukotriene receptor 1 in complex with zafirlukast
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Cysteinyl leukotriene receptor 1,Soluble cytochrome b562,Cysteinyl leukotriene receptor 1 | polymer | 423 | 47927.1 | 2 | UniProt (Q9Y271) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361) In PDB | Homo sapiens (Human) | CysLTR1,Cysteinyl leukotriene D4 receptor,LTD4 receptor,G-protein coupled receptor HG55,HMTMF81,Cytochrome b-562,CysLTR1,Cysteinyl leukotriene D4 receptor,LTD4 receptor,G-protein coupled receptor HG55,HMTMF81 |
2 | A, B | zafirlukast | non-polymer | 575.7 | 3 | Chemie (ZLK) | |||
3 | B, A | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 17 | Chemie (OLC) | |||
4 | B, A | OLEIC ACID | non-polymer | 282.5 | 19 | Chemie (OLA) | |||
5 | A | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) | |||
6 | B, A | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
7 | water | water | 18.0 | 10 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 222 (UniProt: Q9Y271)
A, B: 1001 - 1105 (UniProt: P0ABE7)
A, B: null - 311 (UniProt: Q9Y271)
PDB | External Database | Details |
---|---|---|
Gly -2 | - | expression tag |
Gly -1 | - | expression tag |
Thr 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Trp 1007 | Met 29 | conflict |
Ile 1102 | His 124 | conflict |
Leu 1106 | - | linker |
Ser | - | linker |
Gly | - | linker |
PDB | External Database | Details |
---|---|---|
Ser 1000 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 95854.2 | |
Non-Polymers* | Number of molecules | 42 |
Total formula weight | 13439.2 | |
All* | Total formula weight | 109293.4 |