6RZ5
XFEL crystal structure of the human cysteinyl leukotriene receptor 1 in complex with zafirlukast
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004930 | molecular_function | G protein-coupled receptor activity |
| A | 0004974 | molecular_function | leukotriene receptor activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016020 | cellular_component | membrane |
| A | 0020037 | molecular_function | heme binding |
| A | 0022900 | biological_process | electron transport chain |
| A | 0042597 | cellular_component | periplasmic space |
| B | 0004930 | molecular_function | G protein-coupled receptor activity |
| B | 0004974 | molecular_function | leukotriene receptor activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0016020 | cellular_component | membrane |
| B | 0020037 | molecular_function | heme binding |
| B | 0022900 | biological_process | electron transport chain |
| B | 0042597 | cellular_component | periplasmic space |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 216 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | MET1-THR28 | |
| A | ARG79-ASN106 | |
| A | PRO163-SER193 | |
| A | GLN252-SER276 | |
| B | MET1-THR28 | |
| B | ARG79-ASN106 | |
| B | PRO163-SER193 | |
| B | GLN252-SER276 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU29-ILE49 | |
| B | LEU29-ILE49 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | LYS50-ALA57 | |
| A | PRO128-ARG141 | |
| B | LYS50-ALA57 | |
| B | PRO128-ARG141 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE58-LEU78 | |
| B | PHE58-LEU78 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU107-PHE127 | |
| B | LEU107-PHE127 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| A | PHE142-LYS162 | |
| B | PHE142-LYS162 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU194-LEU214 | |
| B | LEU194-LEU214 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA231-ILE251 | |
| B | ALA231-ILE251 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL277-PHE297 | |
| B | VAL277-PHE297 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN6 | |
| A | ASN169 | |
| A | ASN180 | |
| A | ASN262 | |
| B | ASN6 | |
| B | ASN169 | |
| B | ASN180 | |
| B | ASN262 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | BINDING: axial binding residue |
| Chain | Residue | Details |
| A | TRP1007 | |
| A | ILE1102 | |
| B | TRP1007 | |
| B | ILE1102 |
