6RZ3

Crystal structure of a complex between the DNA-binding domain of p53 and the carboxyl-terminal conserved region of iASPP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Cellular tumor antigen p53	polymer	232	25660.3	1	UniProt (P04637) Pfam (PF00870)	Homo sapiens (Human)	Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53
2	B (B)	RelA-associated inhibitor	polymer	238	26132.0	1	UniProt (Q8WUF5) Pfam (PF12796) Pfam (PF14604)	Homo sapiens (Human)	Inhibitor of ASPP protein,Protein iASPP,NFkB-interacting protein 1,PPP1R13B-like protein
3	C (A)	ZINC ION	non-polymer		65.4	1	Chemie (ZN)

Sequence modifications

A: 62 - 292 (UniProt: P04637)

PDB	External Database	Details
Met 61	-	initiating methionine

B: 625 - 828 (UniProt: Q8WUF5)

PDB	External Database	Details
Met 624	-	initiating methionine
Leu 829	-	expression tag
Glu 830	-	expression tag
Gly 831	-	expression tag
Gly 832	-	expression tag
Ser 833	-	expression tag
Gly 834	-	expression tag
Gly 835	-	expression tag
Ser 836	-	expression tag
Gly 837	-	expression tag
Leu 838	-	expression tag
Asn 839	-	expression tag
Asp 840	-	expression tag
Ile 841	-	expression tag
Phe 842	-	expression tag
Glu 843	-	expression tag
Ala 844	-	expression tag
Gln 845	-	expression tag
Lys 846	-	expression tag
Ile 847	-	expression tag
Glu 848	-	expression tag
Trp 849	-	expression tag
His 850	-	expression tag
Glu 851	-	expression tag
Gly 852	-	expression tag
Arg 853	-	expression tag
Thr 854	-	expression tag
Lys 855	-	expression tag
His 856	-	expression tag
His 857	-	expression tag
His 858	-	expression tag
His 859	-	expression tag
His 860	-	expression tag
His 861	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	51792.2
Non-Polymers*	Number of molecules	1
	Total formula weight	65.4
All*	Total formula weight	51857.6

*Water molecules are not included.