6RTY

Crystal structure of the Patched ectodomain in complex with nanobody NB64

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Protein patched homolog 1	polymer	297	34138.8	1	UniProt (Q13635) In PDB	Homo sapiens (Human)	PTC1
2	B	Llama-derived nanobody NB64	polymer	130	14043.6	1		Lama glama
3	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	3	Chemie (NAG)
4		water	water		18.0	79	Chemie (HOH)

Sequence modifications

A: 136 - 423 (UniProt: Q13635)

PDB	External Database	Details
Glu 136	Val 136	conflict
Thr 137	Ser 137	conflict
Gly 138	Arg 138	conflict
Gly 424	-	expression tag
Thr 425	-	expression tag
Lys 426	-	expression tag
His 427	-	expression tag
His 428	-	expression tag
His 429	-	expression tag
His 430	-	expression tag
His 431	-	expression tag
His 432	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	48182.3
Non-Polymers*	Number of molecules	3
	Total formula weight	663.6
All*	Total formula weight	48845.9

*Water molecules are not included.