6RTI
X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with aptamer A9g
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Glutamate carboxypeptidase 2 | polymer | 707 | 79614.8 | 1 | UniProt (Q04609) Pfam (PF02225) Pfam (PF04389) Pfam (PF04253) | Homo sapiens (Human) | Cell growth-inhibiting gene 27 protein,Folate hydrolase 1,Folylpoly-gamma-glutamate carboxypeptidase,FGCP,Glutamate carboxypeptidase II,GCPII,Membrane glutamate carboxypeptidase,mGCP,N-acetylated-alpha-linked acidic dipeptidase I,NAALADase I,Prostate-specific membrane antigen,PSMA,Pteroylpoly-gamma-glutamate carboxypeptidase |
| 2 | B (X) | Aptamer A9g, RNA (43-MER) | polymer | 43 | 13764.0 | 1 | synthetic construct | ||
| 3 | C, E, H (B, D, G) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
| 4 | D, F, I (C, E, H) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 5 | G (F) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
| 6 | J, K (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 7 | L (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 8 | M (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 9 | N (A) | (2S)-2-(PHOSPHONOMETHYL)PENTANEDIOIC ACID | non-polymer | 226.1 | 1 | Chemie (G88) | |||
| 10 | O, P, Q, S, T... (A, X) | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 6 | Chemie (MPD) | |||
| 11 | R (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 12 | V, W (A, X) | water | water | 18.0 | 401 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 93378.8 | |
| Branched | Number of molecules | 7 |
| Total formula weight | 3781.5 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1200.6 | |
| All* | Total formula weight | 98360.8 |
