6RTI

X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with aptamer A9g

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Glutamate carboxypeptidase 2	polymer	707	79614.8	1	UniProt (Q04609) Pfam (PF02225) Pfam (PF04389) Pfam (PF04253) In PDB	Homo sapiens (Human)	Cell growth-inhibiting gene 27 protein,Folate hydrolase 1,Folylpoly-gamma-glutamate carboxypeptidase,FGCP,Glutamate carboxypeptidase II,GCPII,Membrane glutamate carboxypeptidase,mGCP,N-acetylated-alpha-linked acidic dipeptidase I,NAALADase I,Prostate-specific membrane antigen,PSMA,Pteroylpoly-gamma-glutamate carboxypeptidase
2	X	Aptamer A9g, RNA (43-MER)	polymer	43	13764.0	1		synthetic construct
3	B, D, G	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	3	In PDB GlyTouCan (G15407YE)
4	C, E, H	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	3	In PDB GlyTouCan (G42666HT)
5	F	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81315DD)
6	A	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
7	A	CHLORIDE ION	non-polymer		35.5	1	Chemie (CL)
8	A	CALCIUM ION	non-polymer		40.1	1	Chemie (CA)
9	A	(2S)-2-(PHOSPHONOMETHYL)PENTANEDIOIC ACID	non-polymer		226.1	1	Chemie (G88)
10	A, X	(4S)-2-METHYL-2,4-PENTANEDIOL	non-polymer		118.2	6	Chemie (MPD)
11	A	ACETATE ION	non-polymer		59.0	1	Chemie (ACT)
12		water	water		18.0	401	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	93378.8
Branched	Number of molecules	7
	Total formula weight	3781.5
Non-Polymers*	Number of molecules	12
	Total formula weight	1200.6
All*	Total formula weight	98360.8

*Water molecules are not included.