6RQX

High-resolution crystal structure of ERAP1 in complex with 10mer phosphinic peptide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Endoplasmic reticulum aminopeptidase 1	polymer	938	106939.0	1	UniProt (Q9NZ08) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) In PDB	Homo sapiens (Human)	ARTS-1,Adipocyte-derived leucine aminopeptidase,A-LAP,Aminopeptidase PILS,Puromycin-insensitive leucyl-specific aminopeptidase,PILS-AP,Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
2	B	PSE-LYS-HIS-HIS-ALA-PHE-SER-PHE-LYS	polymer	9	1298.5	1		Homo sapiens
3	C	alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		570.5	1	In PDB GlyTouCan (G11971MR)
4	D	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1	In PDB GlyTouCan (G81315DD)
5	E	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
6	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
7	A	ZINC ION	non-polymer		65.4	1	Chemie (ZN)
8	A	THIOCYANATE ION	non-polymer		58.1	11	Chemie (SCN)
9	A	1,2-ETHANEDIOL	non-polymer		62.1	22	Chemie (EDO)
10	A	SODIUM ION	non-polymer		23.0	4	Chemie (NA)
11	A	TRIETHYLENE GLYCOL	non-polymer		150.2	3	Chemie (PGE)
12		water	water		18.0	736	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	108237.6
Branched	Number of molecules	3
	Total formula weight	1743.6
Non-Polymers*	Number of molecules	42
	Total formula weight	2833.5
All*	Total formula weight	112814.7

*Water molecules are not included.