6RQX

High-resolution crystal structure of ERAP1 in complex with 10mer phosphinic peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001525	biological_process	angiogenesis
A	0002250	biological_process	adaptive immune response
A	0002376	biological_process	immune system process
A	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
A	0004175	molecular_function	endopeptidase activity
A	0004177	molecular_function	aminopeptidase activity
A	0005138	molecular_function	interleukin-6 receptor binding
A	0005151	molecular_function	interleukin-1, type II receptor binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0006508	biological_process	proteolysis
A	0006509	biological_process	membrane protein ectodomain proteolysis
A	0008217	biological_process	regulation of blood pressure
A	0008233	molecular_function	peptidase activity
A	0008235	molecular_function	metalloexopeptidase activity
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0009617	biological_process	response to bacterium
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
A	0042277	molecular_function	peptide binding
A	0043171	biological_process	peptide catabolic process
A	0045088	biological_process	regulation of innate immune response
A	0045444	biological_process	fat cell differentiation
A	0045766	biological_process	positive regulation of angiogenesis
A	0046872	molecular_function	metal ion binding
A	0070006	molecular_function	metalloaminopeptidase activity
A	0070062	cellular_component	extracellular exosome

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TVAHELAHQW

Chain	Residue	Details
A	THR350-TRP359

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	MET1

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site_id	SWS_FT_FI2
Number of Residues	19
Details	TRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000255

Chain	Residue	Details
A	VAL2-LEU21

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site_id	SWS_FT_FI3
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10095

Chain	Residue	Details
A	GLU354

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site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	GLU183
A	GLY317

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site_id	SWS_FT_FI5
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
A	HIS353
A	HIS357
A	GLU376

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site_id	SWS_FT_FI6
Number of Residues	1
Details	SITE: Transition state stabilizer => ECO:0000250

Chain	Residue	Details
A	TYR438

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site_id	SWS_FT_FI7
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21478864, ECO:0000269|Ref.16

Chain	Residue	Details
A	ASN70
A	ASN154

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site_id	SWS_FT_FI8
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|Ref.16

Chain	Residue	Details
A	ASN414

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site_id	SWS_FT_FI9
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21478864

Chain	Residue	Details
A	ASN760

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site_id	SWS_FT_FI10
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN901

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