6RNK
Crystal structure of a humanized (K18E, K269N) rat succinate receptor SUCNR1 (GPR91) in complex with a nanobody and antagonist NF-56-EJ40.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Succinate receptor 1 | polymer | 342 | 39827.7 | 1 | UniProt (Q6IYF9) Pfam (PF00001) In PDB | Rattus norvegicus (Rat) | G-protein coupled receptor 91 |
2 | B | Nanobody6 | polymer | 142 | 15527.1 | 1 | Vicugna pacos | ||
3 | A | 2-[2-[[3-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]phenyl]carbonylamino]phenyl]ethanoic acid | non-polymer | 443.5 | 1 | Chemie (KAZ) | |||
4 | A | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 13 | Chemie (OLC) | |||
5 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
6 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
7 | water | water | 18.0 | 242 | Chemie (HOH) |
Sequence modifications
A: 2 - 317 (UniProt: Q6IYF9)
PDB | External Database | Details |
---|---|---|
Asp -6 | - | expression tag |
Tyr -5 | - | expression tag |
Lys -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Asp -1 | - | expression tag |
Asp 0 | - | expression tag |
Lys 1 | - | expression tag |
Glu 18 | Lys 18 | engineered mutation |
Asn 269 | Lys 269 | engineered mutation |
Leu 318 | - | expression tag |
Glu 319 | - | expression tag |
Val 320 | - | expression tag |
Leu 321 | - | expression tag |
Phe 322 | - | expression tag |
Gln 323 | - | expression tag |
Gly 324 | - | expression tag |
Pro 325 | - | expression tag |
His 326 | - | expression tag |
His 327 | - | expression tag |
His 328 | - | expression tag |
His 329 | - | expression tag |
His 330 | - | expression tag |
His 331 | - | expression tag |
His 332 | - | expression tag |
His 333 | - | expression tag |
His 334 | - | expression tag |
His 335 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 55354.8 | |
Non-Polymers* | Number of molecules | 16 |
Total formula weight | 5266.7 | |
All* | Total formula weight | 60621.5 |