6RNK

Crystal structure of a humanized (K18E, K269N) rat succinate receptor SUCNR1 (GPR91) in complex with a nanobody and antagonist NF-56-EJ40.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002001	biological_process	renin secretion into blood stream
A	0002281	biological_process	macrophage activation involved in immune response
A	0004930	molecular_function	G protein-coupled receptor activity
A	0005886	cellular_component	plasma membrane
A	0007165	biological_process	signal transduction
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0016020	cellular_component	membrane
A	0038023	molecular_function	signaling receptor activity
A	0042593	biological_process	glucose homeostasis
A	0050729	biological_process	positive regulation of inflammatory response
A	0050921	biological_process	positive regulation of chemotaxis
A	0051592	biological_process	response to calcium ion
A	0060177	biological_process	regulation of angiotensin metabolic process
A	0097009	biological_process	energy homeostasis

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue KAZ A 401

Chain	Residue
A	GLU18
A	CYS168
A	TYR244
A	ARG276
A	PHE280
A	GOL415
A	HOH510
A	TYR26
A	SER78
A	TYR79
A	GLY82
A	TRP84
A	ASN94
A	ARG95
A	LEU98

---

site_id	AC2
Number of Residues	9
Details	binding site for residue OLC A 402

Chain	Residue
A	TYR57
A	PHE111
A	ILE114
A	ASP115
A	LEU129
A	PHE134
A	ILE138
A	OLC403
A	OLC408

---

site_id	AC3
Number of Residues	9
Details	binding site for residue OLC A 403

Chain	Residue
A	ILE114
A	TYR117
A	ILE128
A	LEU129
A	LEU137
A	PHE201
A	OLC402
A	OLC404
A	HOH564

---

site_id	AC4
Number of Residues	10
Details	binding site for residue OLC A 404

Chain	Residue
A	TRP51
A	LYS131
A	LYS132
A	GLU133
A	PHE201
A	OLC403
A	OLC408
A	HOH521
A	HOH550
B	THR118

---

site_id	AC5
Number of Residues	7
Details	binding site for residue OLC A 405

Chain	Residue
A	PHE156
A	THR158
A	GLY175
A	ASN176
A	TYR179
A	SER180
A	TYR183

---

site_id	AC6
Number of Residues	8
Details	binding site for residue OLC A 406

Chain	Residue
A	LYS49
A	TRP51
A	ASN60
A	LYS132
A	ILE136
A	SER139
A	TRP143
A	OLC409

---

site_id	AC7
Number of Residues	3
Details	binding site for residue OLC A 407

Chain	Residue
A	ALA67
A	SER93
A	ASN94

---

site_id	AC8
Number of Residues	5
Details	binding site for residue OLC A 408

Chain	Residue
A	SER197
A	VAL198
A	TYR204
A	OLC402
A	OLC404

---

site_id	AC9
Number of Residues	4
Details	binding site for residue OLC A 409

Chain	Residue
A	LEU45
A	TRP51
A	PHE59
A	OLC406

---

site_id	AD1
Number of Residues	4
Details	binding site for residue OLC A 410

Chain	Residue
A	LEU185
A	PHE192
A	VAL250
A	HOH548

---

site_id	AD2
Number of Residues	3
Details	binding site for residue OLC A 411

Chain	Residue
A	ILE182
A	CYS186
A	LEU189

---

site_id	AD3
Number of Residues	4
Details	binding site for residue OLC A 412

Chain	Residue
A	TYR21
A	ILE246
A	MET247
A	VAL250

---

site_id	AD4
Number of Residues	4
Details	binding site for residue OLC A 413

Chain	Residue
A	TRP10
A	LEU17
A	TYR20
A	ALA267

---

site_id	AD5
Number of Residues	9
Details	binding site for residue OLC A 414

Chain	Residue
A	TYR86
A	GLY87
A	ASP88
A	VAL89
A	LEU90
A	TYR96
A	HOH541
A	HOH554
B	GLY17

---

site_id	AD6
Number of Residues	8
Details	binding site for residue GOL A 415

Chain	Residue
A	KAZ401
A	HOH524
A	HOH559
A	TYR79
A	ARG95
A	CYS168
A	ASP170
A	ARG276

---

site_id	AD7
Number of Residues	6
Details	binding site for residue SO4 A 416

Chain	Residue
A	HIS127
A	HIS127
A	ILE128
A	ILE128
A	LEU129
A	LEU129

---

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. TSIlFLTFISIDRYLlM

Chain	Residue	Details
A	THR104-MET120

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	48
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---