6RMU

Crystal structure of disulphide-linked human C3d dimer in complex with Staphylococcus aureus complement subversion protein Sbi-IV

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, B)	Complement C3	polymer	310	34778.8	2	UniProt (P01024) Pfam (PF07678)	Homo sapiens (Human)	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
2	B, D (C, D)	Immunoglobulin-binding protein Sbi	polymer	81	9269.5	2	UniProt (Q931F4) Pfam (PF11621) UniProt (by SIFTS) (Q2FVK5)	Staphylococcus aureus subsp. aureus Mu50
3	E (A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
4	F (B)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
5	G, H, I, J (A, C, B, D)	water	water		18.0	259	Chemie (HOH)

Sequence modifications

A, B: 3 - 310 (UniProt: P01024)

PDB	External Database	Details
Met 1	-	initiating methionine
Leu 2	-	expression tag

C, D: 12 - 80 (UniProt: Q931F4)

PDB	External Database	Details
Met 0	-	initiating methionine
Arg 1	-	expression tag
Gly 2	-	expression tag
Ser 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
Gly 10	-	expression tag
Ser 11	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	88096.6
Non-Polymers*	Number of molecules	2
	Total formula weight	168.2
All*	Total formula weight	88264.8

*Water molecules are not included.