6R7D
Crystal structure of LTC4S in complex with AZ13690257
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Leukotriene C4 synthase | polymer | 157 | 17482.6 | 12 | UniProt (Q16873) Pfam (PF01124) | Homo sapiens (Human) | LTC4 synthase,Leukotriene-C(4) synthase |
| 2 | CA, DB, GB, JA, KB... (C, H, I, D, J...) | (1~{S},2~{S})-2-[5-[cyclopropylmethyl(naphthalen-1-yl)amino]-4-methoxy-pyrimidin-2-yl]carbonylcyclopropane-1-carboxylic acid | non-polymer | 417.5 | 12 | Chemie (JUQ) | |||
| 3 | DA, HB, KA, LB, N... (C, I, D, J, A...) | NICKEL (II) ION | non-polymer | 58.7 | 8 | Chemie (NI) | |||
| 4 | AA, AB, BB, CB, EA... (B, G, C, H, I...) | PALMITIC ACID | non-polymer | 256.4 | 43 | Chemie (PLM) | |||
| 5 | BA (B) | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 1 | Chemie (LMT) | |||
| 6 | AC, BC, CC, DC, EC... (C, D, E, F, G...) | water | water | 18.0 | 97 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L: 2 - 150 (UniProt: Q16873)
| PDB | External Database | Details |
|---|---|---|
| Met -6 | - | initiating methionine |
| Ala -5 | - | expression tag |
| His -4 | - | expression tag |
| His -3 | - | expression tag |
| His -2 | - | expression tag |
| His -1 | - | expression tag |
| His 0 | - | expression tag |
| His 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 12 |
| Total formula weight | 209791.5 | |
| Non-Polymers* | Number of molecules | 64 |
| Total formula weight | 17015.9 | |
| All* | Total formula weight | 226807.3 |
