6R7D
Crystal structure of LTC4S in complex with AZ13690257
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Leukotriene C4 synthase | polymer | 157 | 17482.6 | 12 | UniProt (Q16873) Pfam (PF01124) In PDB | Homo sapiens (Human) | LTC4 synthase,Leukotriene-C(4) synthase |
2 | C, H, I, D, J... | (1~{S},2~{S})-2-[5-[cyclopropylmethyl(naphthalen-1-yl)amino]-4-methoxy-pyrimidin-2-yl]carbonylcyclopropane-1-carboxylic acid | non-polymer | 417.5 | 12 | Chemie (JUQ) | |||
3 | C, I, D, J, A... | NICKEL (II) ION | non-polymer | 58.7 | 8 | Chemie (NI) | |||
4 | B, G, C, H, I... | PALMITIC ACID | non-polymer | 256.4 | 43 | Chemie (PLM) | |||
5 | B | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 1 | Chemie (LMT) | |||
6 | water | water | 18.0 | 97 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L: 2 - 150 (UniProt: Q16873)
PDB | External Database | Details |
---|---|---|
Met -6 | - | initiating methionine |
Ala -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
His -1 | - | expression tag |
His 0 | - | expression tag |
His 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 12 |
Total formula weight | 209791.5 | |
Non-Polymers* | Number of molecules | 64 |
Total formula weight | 17015.9 | |
All* | Total formula weight | 226807.3 |