6R7D

Crystal structure of LTC4S in complex with AZ13690257

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004364	molecular_function	glutathione transferase activity
A	0004464	molecular_function	leukotriene-C4 synthase activity
A	0004602	molecular_function	glutathione peroxidase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005640	cellular_component	nuclear outer membrane
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006629	biological_process	lipid metabolic process
A	0006691	biological_process	leukotriene metabolic process
A	0008047	molecular_function	enzyme activator activity
A	0008289	molecular_function	lipid binding
A	0016020	cellular_component	membrane
A	0016740	molecular_function	transferase activity
A	0016829	molecular_function	lyase activity
A	0019370	biological_process	leukotriene biosynthetic process
A	0031965	cellular_component	nuclear membrane
A	0042759	biological_process	long-chain fatty acid biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0046394	biological_process	carboxylic acid biosynthetic process
A	0098869	biological_process	cellular oxidant detoxification
B	0004364	molecular_function	glutathione transferase activity
B	0004464	molecular_function	leukotriene-C4 synthase activity
B	0004602	molecular_function	glutathione peroxidase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005635	cellular_component	nuclear envelope
B	0005640	cellular_component	nuclear outer membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0006629	biological_process	lipid metabolic process
B	0006691	biological_process	leukotriene metabolic process
B	0008047	molecular_function	enzyme activator activity
B	0008289	molecular_function	lipid binding
B	0016020	cellular_component	membrane
B	0016740	molecular_function	transferase activity
B	0016829	molecular_function	lyase activity
B	0019370	biological_process	leukotriene biosynthetic process
B	0031965	cellular_component	nuclear membrane
B	0042759	biological_process	long-chain fatty acid biosynthetic process
B	0042802	molecular_function	identical protein binding
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0046394	biological_process	carboxylic acid biosynthetic process
B	0098869	biological_process	cellular oxidant detoxification
C	0004364	molecular_function	glutathione transferase activity
C	0004464	molecular_function	leukotriene-C4 synthase activity
C	0004602	molecular_function	glutathione peroxidase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005635	cellular_component	nuclear envelope
C	0005640	cellular_component	nuclear outer membrane
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0006629	biological_process	lipid metabolic process
C	0006691	biological_process	leukotriene metabolic process
C	0008047	molecular_function	enzyme activator activity
C	0008289	molecular_function	lipid binding
C	0016020	cellular_component	membrane
C	0016740	molecular_function	transferase activity
C	0016829	molecular_function	lyase activity
C	0019370	biological_process	leukotriene biosynthetic process
C	0031965	cellular_component	nuclear membrane
C	0042759	biological_process	long-chain fatty acid biosynthetic process
C	0042802	molecular_function	identical protein binding
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0046394	biological_process	carboxylic acid biosynthetic process
C	0098869	biological_process	cellular oxidant detoxification
D	0004364	molecular_function	glutathione transferase activity
D	0004464	molecular_function	leukotriene-C4 synthase activity
D	0004602	molecular_function	glutathione peroxidase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005635	cellular_component	nuclear envelope
D	0005640	cellular_component	nuclear outer membrane
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0006629	biological_process	lipid metabolic process
D	0006691	biological_process	leukotriene metabolic process
D	0008047	molecular_function	enzyme activator activity
D	0008289	molecular_function	lipid binding
D	0016020	cellular_component	membrane
D	0016740	molecular_function	transferase activity
D	0016829	molecular_function	lyase activity
D	0019370	biological_process	leukotriene biosynthetic process
D	0031965	cellular_component	nuclear membrane
D	0042759	biological_process	long-chain fatty acid biosynthetic process
D	0042802	molecular_function	identical protein binding
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0046394	biological_process	carboxylic acid biosynthetic process
D	0098869	biological_process	cellular oxidant detoxification
E	0004364	molecular_function	glutathione transferase activity
E	0004464	molecular_function	leukotriene-C4 synthase activity
E	0004602	molecular_function	glutathione peroxidase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005635	cellular_component	nuclear envelope
E	0005640	cellular_component	nuclear outer membrane
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0006629	biological_process	lipid metabolic process
E	0006691	biological_process	leukotriene metabolic process
E	0008047	molecular_function	enzyme activator activity
E	0008289	molecular_function	lipid binding
E	0016020	cellular_component	membrane
E	0016740	molecular_function	transferase activity
E	0016829	molecular_function	lyase activity
E	0019370	biological_process	leukotriene biosynthetic process
E	0031965	cellular_component	nuclear membrane
E	0042759	biological_process	long-chain fatty acid biosynthetic process
E	0042802	molecular_function	identical protein binding
E	0043231	cellular_component	intracellular membrane-bounded organelle
E	0046394	biological_process	carboxylic acid biosynthetic process
E	0098869	biological_process	cellular oxidant detoxification
F	0004364	molecular_function	glutathione transferase activity
F	0004464	molecular_function	leukotriene-C4 synthase activity
F	0004602	molecular_function	glutathione peroxidase activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005635	cellular_component	nuclear envelope
F	0005640	cellular_component	nuclear outer membrane
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0006629	biological_process	lipid metabolic process
F	0006691	biological_process	leukotriene metabolic process
F	0008047	molecular_function	enzyme activator activity
F	0008289	molecular_function	lipid binding
F	0016020	cellular_component	membrane
F	0016740	molecular_function	transferase activity
F	0016829	molecular_function	lyase activity
F	0019370	biological_process	leukotriene biosynthetic process
F	0031965	cellular_component	nuclear membrane
F	0042759	biological_process	long-chain fatty acid biosynthetic process
F	0042802	molecular_function	identical protein binding
F	0043231	cellular_component	intracellular membrane-bounded organelle
F	0046394	biological_process	carboxylic acid biosynthetic process
F	0098869	biological_process	cellular oxidant detoxification
G	0004364	molecular_function	glutathione transferase activity
G	0004464	molecular_function	leukotriene-C4 synthase activity
G	0004602	molecular_function	glutathione peroxidase activity
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005635	cellular_component	nuclear envelope
G	0005640	cellular_component	nuclear outer membrane
G	0005783	cellular_component	endoplasmic reticulum
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0006629	biological_process	lipid metabolic process
G	0006691	biological_process	leukotriene metabolic process
G	0008047	molecular_function	enzyme activator activity
G	0008289	molecular_function	lipid binding
G	0016020	cellular_component	membrane
G	0016740	molecular_function	transferase activity
G	0016829	molecular_function	lyase activity
G	0019370	biological_process	leukotriene biosynthetic process
G	0031965	cellular_component	nuclear membrane
G	0042759	biological_process	long-chain fatty acid biosynthetic process
G	0042802	molecular_function	identical protein binding
G	0043231	cellular_component	intracellular membrane-bounded organelle
G	0046394	biological_process	carboxylic acid biosynthetic process
G	0098869	biological_process	cellular oxidant detoxification
H	0004364	molecular_function	glutathione transferase activity
H	0004464	molecular_function	leukotriene-C4 synthase activity
H	0004602	molecular_function	glutathione peroxidase activity
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005635	cellular_component	nuclear envelope
H	0005640	cellular_component	nuclear outer membrane
H	0005783	cellular_component	endoplasmic reticulum
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0006629	biological_process	lipid metabolic process
H	0006691	biological_process	leukotriene metabolic process
H	0008047	molecular_function	enzyme activator activity
H	0008289	molecular_function	lipid binding
H	0016020	cellular_component	membrane
H	0016740	molecular_function	transferase activity
H	0016829	molecular_function	lyase activity
H	0019370	biological_process	leukotriene biosynthetic process
H	0031965	cellular_component	nuclear membrane
H	0042759	biological_process	long-chain fatty acid biosynthetic process
H	0042802	molecular_function	identical protein binding
H	0043231	cellular_component	intracellular membrane-bounded organelle
H	0046394	biological_process	carboxylic acid biosynthetic process
H	0098869	biological_process	cellular oxidant detoxification
I	0004364	molecular_function	glutathione transferase activity
I	0004464	molecular_function	leukotriene-C4 synthase activity
I	0004602	molecular_function	glutathione peroxidase activity
I	0005515	molecular_function	protein binding
I	0005634	cellular_component	nucleus
I	0005635	cellular_component	nuclear envelope
I	0005640	cellular_component	nuclear outer membrane
I	0005783	cellular_component	endoplasmic reticulum
I	0005789	cellular_component	endoplasmic reticulum membrane
I	0006629	biological_process	lipid metabolic process
I	0006691	biological_process	leukotriene metabolic process
I	0008047	molecular_function	enzyme activator activity
I	0008289	molecular_function	lipid binding
I	0016020	cellular_component	membrane
I	0016740	molecular_function	transferase activity
I	0016829	molecular_function	lyase activity
I	0019370	biological_process	leukotriene biosynthetic process
I	0031965	cellular_component	nuclear membrane
I	0042759	biological_process	long-chain fatty acid biosynthetic process
I	0042802	molecular_function	identical protein binding
I	0043231	cellular_component	intracellular membrane-bounded organelle
I	0046394	biological_process	carboxylic acid biosynthetic process
I	0098869	biological_process	cellular oxidant detoxification
J	0004364	molecular_function	glutathione transferase activity
J	0004464	molecular_function	leukotriene-C4 synthase activity
J	0004602	molecular_function	glutathione peroxidase activity
J	0005515	molecular_function	protein binding
J	0005634	cellular_component	nucleus
J	0005635	cellular_component	nuclear envelope
J	0005640	cellular_component	nuclear outer membrane
J	0005783	cellular_component	endoplasmic reticulum
J	0005789	cellular_component	endoplasmic reticulum membrane
J	0006629	biological_process	lipid metabolic process
J	0006691	biological_process	leukotriene metabolic process
J	0008047	molecular_function	enzyme activator activity
J	0008289	molecular_function	lipid binding
J	0016020	cellular_component	membrane
J	0016740	molecular_function	transferase activity
J	0016829	molecular_function	lyase activity
J	0019370	biological_process	leukotriene biosynthetic process
J	0031965	cellular_component	nuclear membrane
J	0042759	biological_process	long-chain fatty acid biosynthetic process
J	0042802	molecular_function	identical protein binding
J	0043231	cellular_component	intracellular membrane-bounded organelle
J	0046394	biological_process	carboxylic acid biosynthetic process
J	0098869	biological_process	cellular oxidant detoxification
K	0004364	molecular_function	glutathione transferase activity
K	0004464	molecular_function	leukotriene-C4 synthase activity
K	0004602	molecular_function	glutathione peroxidase activity
K	0005515	molecular_function	protein binding
K	0005634	cellular_component	nucleus
K	0005635	cellular_component	nuclear envelope
K	0005640	cellular_component	nuclear outer membrane
K	0005783	cellular_component	endoplasmic reticulum
K	0005789	cellular_component	endoplasmic reticulum membrane
K	0006629	biological_process	lipid metabolic process
K	0006691	biological_process	leukotriene metabolic process
K	0008047	molecular_function	enzyme activator activity
K	0008289	molecular_function	lipid binding
K	0016020	cellular_component	membrane
K	0016740	molecular_function	transferase activity
K	0016829	molecular_function	lyase activity
K	0019370	biological_process	leukotriene biosynthetic process
K	0031965	cellular_component	nuclear membrane
K	0042759	biological_process	long-chain fatty acid biosynthetic process
K	0042802	molecular_function	identical protein binding
K	0043231	cellular_component	intracellular membrane-bounded organelle
K	0046394	biological_process	carboxylic acid biosynthetic process
K	0098869	biological_process	cellular oxidant detoxification
L	0004364	molecular_function	glutathione transferase activity
L	0004464	molecular_function	leukotriene-C4 synthase activity
L	0004602	molecular_function	glutathione peroxidase activity
L	0005515	molecular_function	protein binding
L	0005634	cellular_component	nucleus
L	0005635	cellular_component	nuclear envelope
L	0005640	cellular_component	nuclear outer membrane
L	0005783	cellular_component	endoplasmic reticulum
L	0005789	cellular_component	endoplasmic reticulum membrane
L	0006629	biological_process	lipid metabolic process
L	0006691	biological_process	leukotriene metabolic process
L	0008047	molecular_function	enzyme activator activity
L	0008289	molecular_function	lipid binding
L	0016020	cellular_component	membrane
L	0016740	molecular_function	transferase activity
L	0016829	molecular_function	lyase activity
L	0019370	biological_process	leukotriene biosynthetic process
L	0031965	cellular_component	nuclear membrane
L	0042759	biological_process	long-chain fatty acid biosynthetic process
L	0042802	molecular_function	identical protein binding
L	0043231	cellular_component	intracellular membrane-bounded organelle
L	0046394	biological_process	carboxylic acid biosynthetic process
L	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue JUQ A 201

Chain	Residue
A	ASN55
A	TRP116
C	VAL16
C	ALA20
A	TYR59
A	LEU62
A	ARG90
A	TYR93
A	ARG104
A	LEU108
A	ALA112
A	LEU115

---

site_id	AC2
Number of Residues	6
Details	binding site for residue NI A 202

Chain	Residue
A	HIS-1
A	HIS1
B	HIS-1
B	HIS1
C	HIS-1
C	HIS1

---

site_id	AC3
Number of Residues	1
Details	binding site for residue PLM A 203

Chain	Residue
A	PRO132

---

site_id	AC4
Number of Residues	2
Details	binding site for residue PLM A 204

Chain	Residue
A	ARG113
A	LEU117

---

site_id	AC5
Number of Residues	1
Details	binding site for residue PLM A 205

Chain	Residue
A	ALA10

---

site_id	AC6
Number of Residues	4
Details	binding site for residue PLM A 206

Chain	Residue
A	GLU4
A	ILE72
C	LEU64
C	TRP68

---

site_id	AC7
Number of Residues	6
Details	binding site for residue PLM A 207

Chain	Residue
A	HIS0
A	HIS1
A	LEU64
A	TRP68
B	GLU4
B	ILE72

---

site_id	AC8
Number of Residues	11
Details	binding site for residue JUQ B 201

Chain	Residue
A	ALA20
B	ASN55
B	TYR59
B	LEU62
B	ARG90
B	TYR93
B	ARG104
B	LEU108
B	ALA112
B	LEU115
B	TRP116

---

site_id	AC9
Number of Residues	6
Details	binding site for residue NI B 202

Chain	Residue
B	HIS-4
B	HIS-2
F	HIS-4
F	HIS-2
K	HIS-2
K	HIS-4

---

site_id	AD1
Number of Residues	4
Details	binding site for residue PLM B 203

Chain	Residue
A	LYS2
B	PHE74
B	ALA128
H	PRO132

---

site_id	AD2
Number of Residues	2
Details	binding site for residue PLM B 204

Chain	Residue
B	TRP116
B	PLM207

---

site_id	AD3
Number of Residues	4
Details	binding site for residue PLM B 206

Chain	Residue
B	HIS0
B	LEU64
C	GLU4
C	ILE72

---

site_id	AD4
Number of Residues	2
Details	binding site for residue PLM B 207

Chain	Residue
B	TRP116
B	PLM204

---

site_id	AD5
Number of Residues	3
Details	binding site for residue PLM B 208

Chain	Residue
B	GLY77
B	LEU84
H	ARG144

---

site_id	AD6
Number of Residues	4
Details	binding site for residue LMT B 209

Chain	Residue
B	ARG113
B	LEU117
B	ALA120
B	HOH308

---

site_id	AD7
Number of Residues	13
Details	binding site for residue JUQ C 201

Chain	Residue
B	ALA20
B	SER23
C	ASN55
C	TYR59
C	LEU62
C	ARG90
C	TYR93
C	ARG104
C	LEU108
C	SER111
C	ALA112
C	LEU115
C	TRP116

---

site_id	AD8
Number of Residues	6
Details	binding site for residue NI C 202

Chain	Residue
C	HIS-4
C	HIS-2
G	HIS-4
G	HIS-2
J	HIS-2
J	HIS-4

---

site_id	AD9
Number of Residues	4
Details	binding site for residue PLM C 203

Chain	Residue
C	PHE73
C	PHE74
C	HOH305
E	ARG136

---

site_id	AE1
Number of Residues	1
Details	binding site for residue PLM C 204

Chain	Residue
C	TRP116

---

site_id	AE2
Number of Residues	1
Details	binding site for residue PLM C 205

Chain	Residue
C	ARG113

---

site_id	AE3
Number of Residues	1
Details	binding site for residue PLM C 207

Chain	Residue
C	PHE130

---

site_id	AE4
Number of Residues	11
Details	binding site for residue JUQ D 201

Chain	Residue
D	ARG104
D	LEU108
D	LEU115
D	TRP116
F	VAL16
F	ALA20
D	ASN55
D	TYR59
D	LEU62
D	ARG90
D	TYR93

---

site_id	AE5
Number of Residues	6
Details	binding site for residue NI D 202

Chain	Residue
D	HIS-1
D	HIS1
E	HIS-1
E	HIS1
F	HIS-1
F	HIS1

---

site_id	AE6
Number of Residues	1
Details	binding site for residue PLM D 203

Chain	Residue
D	ARG136

---

site_id	AE7
Number of Residues	1
Details	binding site for residue PLM D 204

Chain	Residue
D	PHE130

---

site_id	AE8
Number of Residues	4
Details	binding site for residue PLM D 205

Chain	Residue
D	HIS1
D	GLU4
E	PLM204
F	TRP68

---

site_id	AE9
Number of Residues	6
Details	binding site for residue PLM D 206

Chain	Residue
D	HIS0
D	HIS1
D	LEU64
D	TRP68
E	GLU4
E	ILE72

---

site_id	AF1
Number of Residues	10
Details	binding site for residue JUQ E 201

Chain	Residue
D	ALA20
E	ASN55
E	TYR59
E	LEU62
E	ARG90
E	TYR93
E	ARG104
E	LEU108
E	LEU115
E	TRP116

---

site_id	AF2
Number of Residues	1
Details	binding site for residue PLM E 203

Chain	Residue
E	TYR21

---

site_id	AF3
Number of Residues	3
Details	binding site for residue PLM E 204

Chain	Residue
D	PLM205
E	LEU64
F	ILE72

---

site_id	AF4
Number of Residues	11
Details	binding site for residue JUQ F 201

Chain	Residue
E	ALA20
F	ASN55
F	TYR59
F	LEU62
F	ARG90
F	TYR93
F	ARG104
F	LEU108
F	ALA112
F	LEU115
F	TRP116

---

site_id	AF5
Number of Residues	1
Details	binding site for residue PLM F 202

Chain	Residue
F	LEU84

---

site_id	AF6
Number of Residues	1
Details	binding site for residue PLM F 205

Chain	Residue
F	LEU117

---

site_id	AF7
Number of Residues	11
Details	binding site for residue JUQ G 201

Chain	Residue
G	ASN55
G	TYR59
G	LEU62
G	ARG90
G	TYR93
G	ARG104
G	LEU108
G	ALA112
G	LEU115
G	TRP116
I	ALA20

---

site_id	AF8
Number of Residues	6
Details	binding site for residue NI G 202

Chain	Residue
G	HIS-1
G	HIS1
H	HIS-1
H	HIS1
I	HIS-1
I	HIS1

---

site_id	AF9
Number of Residues	3
Details	binding site for residue PLM G 203

Chain	Residue
F	PHE74
F	ALA128
G	PRO132

---

site_id	AG1
Number of Residues	2
Details	binding site for residue PLM G 204

Chain	Residue
G	ARG113
G	TRP116

---

site_id	AG2
Number of Residues	5
Details	binding site for residue PLM G 205

Chain	Residue
G	HIS0
G	HIS1
G	LEU64
G	TRP68
H	ILE72

---

site_id	AG3
Number of Residues	11
Details	binding site for residue JUQ H 201

Chain	Residue
G	ALA20
H	ASN55
H	TYR59
H	LEU62
H	ARG90
H	TYR93
H	ARG104
H	LEU108
H	ALA112
H	LEU115
H	TRP116

---

site_id	AG4
Number of Residues	2
Details	binding site for residue PLM H 202

Chain	Residue
H	ARG113
H	ALA120

---

site_id	AG5
Number of Residues	1
Details	binding site for residue PLM H 203

Chain	Residue
I	ILE72

---

site_id	AG6
Number of Residues	11
Details	binding site for residue JUQ I 201

Chain	Residue
H	ALA20
I	ASN55
I	TYR59
I	LEU62
I	ARG90
I	TYR93
I	ARG104
I	LEU108
I	ALA112
I	LEU115
I	TRP116

---

site_id	AG7
Number of Residues	6
Details	binding site for residue NI I 202

Chain	Residue
A	HIS-4
A	HIS-2
D	HIS-2
D	HIS-4
I	HIS-4
I	HIS-2

---

site_id	AG8
Number of Residues	1
Details	binding site for residue PLM I 203

Chain	Residue
I	PHE130

---

site_id	AG9
Number of Residues	4
Details	binding site for residue PLM I 204

Chain	Residue
G	GLU4
I	HIS0
I	LEU64
I	TRP68

---

site_id	AH1
Number of Residues	12
Details	binding site for residue JUQ J 201

Chain	Residue
J	ASN55
J	TYR59
J	LEU62
J	ARG90
J	TYR93
J	ARG104
J	LEU108
J	ALA112
J	LEU115
J	TRP116
L	VAL16
L	ALA20

---

site_id	AH2
Number of Residues	6
Details	binding site for residue NI J 202

Chain	Residue
J	HIS-1
J	HIS1
K	HIS-1
K	HIS1
L	HIS-1
L	HIS1

---

site_id	AH3
Number of Residues	1
Details	binding site for residue PLM J 203

Chain	Residue
J	LEU117

---

site_id	AH4
Number of Residues	1
Details	binding site for residue PLM J 204

Chain	Residue
J	TRP116

---

site_id	AH5
Number of Residues	3
Details	binding site for residue PLM J 205

Chain	Residue
D	PHE74
D	ALA128
F	LYS2

---

site_id	AH6
Number of Residues	3
Details	binding site for residue PLM J 206

Chain	Residue
J	GLU4
J	ILE72
L	LEU64

---

site_id	AH7
Number of Residues	4
Details	binding site for residue PLM J 207

Chain	Residue
J	HIS0
J	LEU64
K	GLU4
K	ILE72

---

site_id	AH8
Number of Residues	10
Details	binding site for residue JUQ K 201

Chain	Residue
J	ALA20
K	ASN55
K	TYR59
K	LEU62
K	ARG90
K	TYR93
K	ARG104
K	LEU108
K	LEU115
K	TRP116

---

site_id	AH9
Number of Residues	13
Details	binding site for residue JUQ L 201

Chain	Residue
K	ALA20
K	SER23
L	ASN55
L	TYR59
L	LEU62
L	ARG90
L	TYR93
L	ARG104
L	LEU108
L	SER111
L	ALA112
L	LEU115
L	TRP116

---

site_id	AI1
Number of Residues	6
Details	binding site for residue NI L 202

Chain	Residue
E	HIS-4
E	HIS-2
H	HIS-4
H	HIS-2
L	HIS-2
L	HIS-4

---

site_id	AI2
Number of Residues	1
Details	binding site for residue PLM L 203

Chain	Residue
L	LEU127

---

site_id	AI3
Number of Residues	2
Details	binding site for residue PLM L 204

Chain	Residue
A	PHE74
A	ALA128

---

site_id	AI4
Number of Residues	4
Details	binding site for residue PLM L 205

Chain	Residue
K	HIS1
K	TRP68
L	GLU4
L	ILE72

---

site_id	AI5
Number of Residues	1
Details	binding site for residue PLM L 206

Chain	Residue
L	TRP116

---

Functional Information from PROSITE/UniProt

site_id	PS01297
Number of Residues	15
Details	FLAP_GST2_LTC4S FLAP/GST2/LTC4S family signature. GppeFERVYrAQvNC

Chain	Residue	Details
A	GLY42-CYS56

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	948
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"12023288","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17632546","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17632548","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	348
Details	Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"12023288","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17632546","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17632548","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	36
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"12023288","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17632546","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"17632548","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"17632548","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"17632548","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17632546","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17632548","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27365393","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	108
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17632548","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine; by RPS6KB1","evidences":[{"source":"PubMed","id":"27365393","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---