6R63

Crystal structure of indoleamine 2,3-dioxygenase 1 (IDO1) in complex with ferric heme and MMG-0358

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Indoleamine 2,3-dioxygenase 1	polymer	423	47504.5	2	UniProt (P14902) Pfam (PF01231) In PDB	Homo sapiens (Human)	IDO-1,Indoleamine-pyrrole 2,3-dioxygenase
2	A, B	PROTOPORPHYRIN IX CONTAINING FE	non-polymer		616.5	2	Chemie (HEM)
3	A, B	4-chloranyl-2-(2~{H}-1,2,3-triazol-4-yl)phenol	non-polymer		195.6	3	Chemie (JTB)

Sequence modifications

A, B: 1 - 403 (UniProt: P14902)

PDB	External Database	Details
Met -19	-	initiating methionine
Gly -18	-	expression tag
Ser -17	-	expression tag
Ser -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
His -11	-	expression tag
His -10	-	expression tag
Ser -9	-	expression tag
Ser -8	-	expression tag
Gly -7	-	expression tag
Leu -6	-	expression tag
Val -5	-	expression tag
Pro -4	-	expression tag
Arg -3	-	expression tag
Gly -2	-	expression tag
Ser -1	-	expression tag
His 0	-	expression tag
Ser 3	His 3	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	95009.0
Non-Polymers*	Number of molecules	5
	Total formula weight	1819.8
All*	Total formula weight	96828.8

*Water molecules are not included.