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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6R4O

Structure of a truncated adenylyl cyclase bound to MANT-GTP, forskolin and an activated stimulatory Galphas protein

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Adenylate cyclase 9polymer1533170952.01UniProt (E1BM79)
Pfam (PF00211)		Bos taurus (Bovine)Adenylyl CYclase family member (Acy-1)-like
2B
(B)		Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortpolymer40547003.81UniProt (P04896)
Pfam (PF00503)		Bos taurus (Bovine)Adenylate cyclase-stimulating G alpha protein
3C
(A)		3'-O-(N-METHYLANTHRANILOYL)-GUANOSINE-5'-TRIPHOSPHATEnon-polymer656.31Chemie (ONM)
4D
(A)		FORSKOLINnon-polymer410.51Chemie (FOK)
5E, F
(A)		MANGANESE (II) IONnon-polymer54.92Chemie (MN)
6G
(B)		5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATEnon-polymer539.21Chemie (GSP)
7H
(B)		MAGNESIUM IONnon-polymer24.31Chemie (MG)
Sequence modifications
A: 1 - 1250 (UniProt: E1BM79)
PDBExternal DatabaseDetails
Ala 1251-expression tag
Ala 1252-expression tag
Ala 1253-expression tag
Leu 1254-expression tag
Glu 1255-expression tag
Val 1256-expression tag
Leu 1257-expression tag
Phe 1258-expression tag
Gln 1259-expression tag
Gly 1260-expression tag
Pro 1261-expression tag
Gly 1262-expression tag
Gly 1263-expression tag
Val 1264-expression tag
Ser 1265-expression tag
Lys 1266-expression tag
Gly 1267-expression tag
Glu 1268-expression tag
Glu 1269-expression tag
Leu 1270-expression tag
Phe 1271-expression tag
Thr 1272-expression tag
Gly 1273-expression tag
Val 1274-expression tag
Val 1275-expression tag
Pro 1276-expression tag
Ile 1277-expression tag
Leu 1278-expression tag
Val 1279-expression tag
Glu 1280-expression tag
Leu 1281-expression tag
Asp 1282-expression tag
Gly 1283-expression tag
Asp 1284-expression tag
Val 1285-expression tag
Asn 1286-expression tag
Gly 1287-expression tag
His 1288-expression tag
Lys 1289-expression tag
Phe 1290-expression tag
Ser 1291-expression tag
Val 1292-expression tag
Ser 1293-expression tag
Gly 1294-expression tag
Glu 1295-expression tag
Gly 1296-expression tag
Glu 1297-expression tag
Gly 1298-expression tag
Asp 1299-expression tag
Ala 1300-expression tag
Thr 1301-expression tag
Tyr 1302-expression tag
Gly 1303-expression tag
Lys 1304-expression tag
Leu 1305-expression tag
Thr 1306-expression tag
Leu 1307-expression tag
Lys 1308-expression tag
Phe 1309-expression tag
Ile 1310-expression tag
Cys 1311-expression tag
Thr 1312-expression tag
Thr 1313-expression tag
Gly 1314-expression tag
Lys 1315-expression tag
Leu 1316-expression tag
Pro 1317-expression tag
Val 1318-expression tag
Pro 1319-expression tag
Trp 1320-expression tag
Pro 1321-expression tag
Thr 1322-expression tag
Leu 1323-expression tag
Val 1324-expression tag
Thr 1325-expression tag
Thr 1326-expression tag
Phe 1327-expression tag
Gly 1328-expression tag
Tyr 1329-expression tag
Gly 1330-expression tag
Leu 1331-expression tag
Gln 1332-expression tag
Cys 1333-expression tag
Phe 1334-expression tag
Ala 1335-expression tag
Arg 1336-expression tag
Tyr 1337-expression tag
Pro 1338-expression tag
Asp 1339-expression tag
His 1340-expression tag
Met 1341-expression tag
Lys 1342-expression tag
Gln 1343-expression tag
His 1344-expression tag
Asp 1345-expression tag
Phe 1346-expression tag
Phe 1347-expression tag
Lys 1348-expression tag
Ser 1349-expression tag
Ala 1350-expression tag
Met 1351-expression tag
Pro 1352-expression tag
Glu 1353-expression tag
Gly 1354-expression tag
Tyr 1355-expression tag
Val 1356-expression tag
Gln 1357-expression tag
Glu 1358-expression tag
Arg 1359-expression tag
Thr 1360-expression tag
Ile 1361-expression tag
Phe 1362-expression tag
Phe 1363-expression tag
Lys 1364-expression tag
Asp 1365-expression tag
Asp 1366-expression tag
Gly 1367-expression tag
Asn 1368-expression tag
Tyr 1369-expression tag
Lys 1370-expression tag
Thr 1371-expression tag
Arg 1372-expression tag
Ala 1373-expression tag
Glu 1374-expression tag
Val 1375-expression tag
Lys 1376-expression tag
Phe 1377-expression tag
Glu 1378-expression tag
Gly 1379-expression tag
Asp 1380-expression tag
Thr 1381-expression tag
Leu 1382-expression tag
Val 1383-expression tag
Asn 1384-expression tag
Arg 1385-expression tag
Ile 1386-expression tag
Glu 1387-expression tag
Leu 1388-expression tag
Lys 1389-expression tag
Gly 1390-expression tag
Ile 1391-expression tag
Asp 1392-expression tag
Phe 1393-expression tag
Lys 1394-expression tag
Glu 1395-expression tag
Asp 1396-expression tag
Gly 1397-expression tag
Asn 1398-expression tag
Ile 1399-expression tag
Leu 1400-expression tag
Gly 1401-expression tag
His 1402-expression tag
Lys 1403-expression tag
Leu 1404-expression tag
Glu 1405-expression tag
Tyr 1406-expression tag
Asn 1407-expression tag
Tyr 1408-expression tag
Asn 1409-expression tag
Ser 1410-expression tag
His 1411-expression tag
Asn 1412-expression tag
Val 1413-expression tag
Tyr 1414-expression tag
Ile 1415-expression tag
Met 1416-expression tag
Ala 1417-expression tag
Asp 1418-expression tag
Lys 1419-expression tag
Gln 1420-expression tag
Lys 1421-expression tag
Asn 1422-expression tag
Gly 1423-expression tag
Ile 1424-expression tag
Lys 1425-expression tag
Val 1426-expression tag
Asn 1427-expression tag
Phe 1428-expression tag
Lys 1429-expression tag
Ile 1430-expression tag
Arg 1431-expression tag
His 1432-expression tag
Asn 1433-expression tag
Ile 1434-expression tag
Glu 1435-expression tag
Asp 1436-expression tag
Gly 1437-expression tag
Ser 1438-expression tag
Val 1439-expression tag
Gln 1440-expression tag
Leu 1441-expression tag
Ala 1442-expression tag
Asp 1443-expression tag
His 1444-expression tag
Tyr 1445-expression tag
Gln 1446-expression tag
Gln 1447-expression tag
Asn 1448-expression tag
Thr 1449-expression tag
Pro 1450-expression tag
Ile 1451-expression tag
Gly 1452-expression tag
Asp 1453-expression tag
Gly 1454-expression tag
Pro 1455-expression tag
Val 1456-expression tag
Leu 1457-expression tag
Leu 1458-expression tag
Pro 1459-expression tag
Asp 1460-expression tag
Asn 1461-expression tag
His 1462-expression tag
Tyr 1463-expression tag
Leu 1464-expression tag
Ser 1465-expression tag
Tyr 1466-expression tag
Gln 1467-expression tag
Ser 1468-expression tag
Ala 1469-expression tag
Leu 1470-expression tag
Ser 1471-expression tag
Lys 1472-expression tag
Asp 1473-expression tag
Pro 1474-expression tag
Asn 1475-expression tag
Glu 1476-expression tag
Lys 1477-expression tag
Arg 1478-expression tag
Asp 1479-expression tag
His 1480-expression tag
Met 1481-expression tag
Val 1482-expression tag
Leu 1483-expression tag
Leu 1484-expression tag
Glu 1485-expression tag
Phe 1486-expression tag
Val 1487-expression tag
Thr 1488-expression tag
Ala 1489-expression tag
Ala 1490-expression tag
Gly 1491-expression tag
Ile 1492-expression tag
Thr 1493-expression tag
Leu 1494-expression tag
Gly 1495-expression tag
Met 1496-expression tag
Asp 1497-expression tag
Glu 1498-expression tag
Leu 1499-expression tag
Tyr 1500-expression tag
Lys 1501-expression tag
Ala 1502-expression tag
Ala 1503-expression tag
Ser 1504-expression tag
Ala 1505-expression tag
Trp 1506-expression tag
Ser 1507-expression tag
His 1508-expression tag
Pro 1509-expression tag
Gln 1510-expression tag
Phe 1511-expression tag
Glu 1512-expression tag
Lys 1513-expression tag
Gly 1514-expression tag
Gly 1515-expression tag
Gly 1516-expression tag
Ser 1517-expression tag
Gly 1518-expression tag
Gly 1519-expression tag
Gly 1520-expression tag
Ser 1521-expression tag
Gly 1522-expression tag
Gly 1523-expression tag
Ser 1524-expression tag
Ala 1525-expression tag
Trp 1526-expression tag
Ser 1527-expression tag
His 1528-expression tag
Pro 1529-expression tag
Gln 1530-expression tag
Phe 1531-expression tag
Glu 1532-expression tag
Lys 1533-expression tag
B: 1 - 394 (UniProt: P04896)
PDBExternal DatabaseDetails
Gly 65-insertion
Asn 65Gln 78conflict
Lys 65Arg 81conflict
Gly 395-expression tag
Gly 396-expression tag
His 397-expression tag
His 398-expression tag
His 399-expression tag
His 400-expression tag
His 401-expression tag
His 402-expression tag
His 403-expression tag
His 404-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight217955.8
Non-Polymers*Number of molecules6
Total formula weight1740.3
All*Total formula weight219696.0
*Water molecules are not included.

247536

PDB entries from 2026-01-14

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