6R4L

Crystal structure of S. cerevisia Niemann-Pick type C protein NCR1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	NPC intracellular cholesterol transporter 1-related protein 1	polymer	1198	135491.8	1	UniProt (Q12200) Pfam (PF16414) Pfam (PF02460) In PDB	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)	Niemann-Pick type C-related protein 1
2	B, C	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	2	In PDB GlyTouCan (G15407YE)
3	A	ERGOSTEROL	non-polymer		396.6	1	Chemie (ERG)
4	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)

Sequence modifications

A: 1 - 1170 (UniProt: Q12200)

PDB	External Database	Details
Leu 1171	-	expression tag
Val 1172	-	expression tag
Pro 1173	-	expression tag
Arg 1174	-	expression tag
Gly 1175	-	expression tag
Ser 1176	-	expression tag
Gly 1177	-	expression tag
Gly 1178	-	expression tag
Gly 1179	-	expression tag
Gly 1180	-	expression tag
Ser 1181	-	expression tag
Gly 1182	-	expression tag
Gly 1183	-	expression tag
Gly 1184	-	expression tag
Gly 1185	-	expression tag
Ser 1186	-	expression tag
Gly 1187	-	expression tag
Gly 1188	-	expression tag
His 1189	-	expression tag
His 1190	-	expression tag
His 1191	-	expression tag
His 1192	-	expression tag
His 1193	-	expression tag
His 1194	-	expression tag
His 1195	-	expression tag
His 1196	-	expression tag
His 1197	-	expression tag
His 1198	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	135491.8
Branched	Number of molecules	2
	Total formula weight	1173.1
Non-Polymers*	Number of molecules	3
	Total formula weight	839.1
All*	Total formula weight	137504.0

*Water molecules are not included.