6R2E
Crystal structure of the human thymidylate synthase (hTS) interface variant Q62R
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C, D, B, F... | Thymidylate synthase | polymer | 325 | 37349.8 | 6 | UniProt (P04818) Pfam (PF00303) In PDB | Homo sapiens (Human) | TSase |
2 | E, G | Thymidylate synthase | polymer | 325 | 37319.7 | 2 | UniProt (P04818) Pfam (PF00303) In PDB | Homo sapiens (Human) | TSase |
3 | F, H, A, E, C... | SULFATE ION | non-polymer | 96.1 | 17 | Chemie (SO4) | |||
4 | B, F, H, A, E... | N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid | non-polymer | 473.4 | 8 | Chemie (FFO) | |||
5 | B, A, E, G, C... | CHLORIDE ION | non-polymer | 35.5 | 8 | Chemie (CL) | |||
6 | H, D | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
7 | water | water | 18.0 | 2430 | Chemie (HOH) |
Sequence modifications
A, C, D, B, F, H: 1 - 313 (UniProt: P04818)
E, G: 1 - 313 (UniProt: P04818)
PDB | External Database | Details |
---|---|---|
Met -11 | - | initiating methionine |
Arg -10 | - | expression tag |
Gly -9 | - | expression tag |
Ser -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Arg 62 | Gln 62 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Met -11 | - | initiating methionine |
Arg -10 | - | expression tag |
Gly -9 | - | expression tag |
Ser -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Arg 62 | Gln 62 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 298738.0 | |
Non-Polymers* | Number of molecules | 35 |
Total formula weight | 5888.4 | |
All* | Total formula weight | 304626.4 |